The 3Dpol-3B complexes [Dataset]

Ferrer-Orta, Cristina; Ferrero, Diego; Verdaguer, Núria

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Título:	The 3Dpol-3B complexes [Dataset]
Autor:	Ferrer-Orta, Cristina CSIC ORCID ; Ferrero, Diego CSIC ORCID ; Verdaguer, Núria CSIC ORCID
Palabras clave:	Structural biology approaches Mouth disease virus div >< p Different functions within Almost symmetric way Linked immunosorbent assays Play essential roles Concentrate viral rna Two uridine molecules pol Pol Another critical interaction Animal pathogen foot Region ii presenting Higher binding affinity Binding protein responsible 3b1 complex Dependent rna polymerase 3b1 region ii Pprimer protein 3b Elisa assays show Viral rna Protein primer Region ii Assays show Small protein Replication complex Highest affinity Essential component Functional binding Fmdv 3b1 Replication requires Replication occurs Replication machinery Picornavirus replication Membranous compartments Identical copies Host factors Basic residues Based pull Also participate Also catalysed 3b uridylylation
Fecha de publicación:	1-may-2022
Editor:	Figshare
Citación:	Ferrer-Orta, Cristina; Ferrero, Diego; Verdaguer, Núria; 2023; The 3Dpol-3B complexes [Dataset]; Figshare; https://doi.org/10.1371/journal.ppat.1011373.s002
Resumen:	(A) Cartoon representation of the structure of the FMDV 3Dpol-3B3 complex from trigonal crystals, space group P3221. 3Dpol is shown in ribbons (yellow) and the VPg3 fragment, bound at the bottom of the palm subdomain, is shown as atom type stick (carbons in white). The corresponding 2Fo-Fc electron density map (1.0σ) is also shown around the 3B3 molecule as a light blue mesh. The proximity of a neighbouring 3Dpol molecule (Grey) in the crystal packing probably limits the 3B molecule from being arranged in an ordered way. (B) The Structure of the EV71-3B in complex with 3Dpol. 3Dpol is shown in orange ribbons and the bound VPg is depicted as atom-type sticks at the bottom of palm sub-domain [11] (PDB id 4IKA). (C) Detail of the interactions in the FMDV 3Dpol-3B3 complex.
Versión del editor:	https://doi.org/10.1371/journal.ppat.1011373.s002
URI:	http://hdl.handle.net/10261/351409
DOI:	10.1371/journal.ppat.1011373.s002
Referencias:	Ferrer-Orta, Cristina; Ferrero, Diego; Verdaguer, Núria. Dual role of the foot-and-mouth disease virus 3B1 protein in the replication complex: As protein primer and as an essential component to recruit 3Dpol to membranas. https://doi.org/10.1371/journal.ppat.1011373 . http://hdl.handle.net/10261/335548
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