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http://hdl.handle.net/10261/349895
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dc.contributor.author | Younossi, Zobair M. | es_ES |
dc.contributor.author | Yu, Ming-Lung | es_ES |
dc.contributor.author | Yilmaz, Yusuf | es_ES |
dc.contributor.author | Alswat, Khalid | es_ES |
dc.contributor.author | Buti, Maria | es_ES |
dc.contributor.author | Castellanos Fernandez, Marlen Ivon | es_ES |
dc.contributor.author | Papatheodoridis, Georgios | es_ES |
dc.contributor.author | Hamid, Saeed S. | es_ES |
dc.contributor.author | El-Kassas, Mohamed | es_ES |
dc.contributor.author | Chan, Wah-Kheong | es_ES |
dc.contributor.author | Duseja, Ajay K. | es_ES |
dc.contributor.author | Gordon, Stuart C. | es_ES |
dc.contributor.author | Eguchi, Yuichiro | es_ES |
dc.contributor.author | Isakov, Vasily A. | es_ES |
dc.contributor.author | Roberts, Stuart K. | es_ES |
dc.contributor.author | Fan, Jian-Gao | es_ES |
dc.contributor.author | Singal, Ashwani K. | es_ES |
dc.contributor.author | Romero-Gómez, Manuel | es_ES |
dc.contributor.author | Ahmed, Aijaz | es_ES |
dc.contributor.author | Ong, Janus | es_ES |
dc.contributor.author | Lam, Brian P. | es_ES |
dc.contributor.author | Younossi, Issah | es_ES |
dc.contributor.author | Nader, Fatema | es_ES |
dc.contributor.author | Racila, Andrei | es_ES |
dc.contributor.author | Stepanova, Maria | es_ES |
dc.contributor.author | Alqahtani, Saleh | es_ES |
dc.date.accessioned | 2024-03-11T10:04:16Z | - |
dc.date.available | 2024-03-11T10:04:16Z | - |
dc.date.issued | 2023-04 | - |
dc.identifier.citation | Journal of Viral Hepatitis 30(4): 335-344 (2023) | es_ES |
dc.identifier.issn | 1352-0504 | - |
dc.identifier.uri | http://hdl.handle.net/10261/349895 | - |
dc.description.abstract | Chronic hepatitis B (CHB) infection is one of the most common causes of cirrhosis and liver cancer worldwide. Our aim was to assess clinical and patient-reported outcome (PRO) profile of CHB patients from different regions of the world using the Global Liver Registry. The CHB patients seen in real-world practices are being enrolled in the Global Liver Registry. Clinical and PRO (FACIT-F, CLDQ, WPAI) data were collected and compared to baseline data from CHB controls from clinical trials. The study included 1818 HBV subjects (48 ± 13 years, 58% male, 14% advanced fibrosis, 7% cirrhosis) from 15 countries in 6/7 Global Burden of Disease super-regions. The rates of advanced fibrosis varied (3–24%). The lowest PRO scores across multiple domains were in HBV subjects from the Middle East/North Africa (MENA), the highest – Southeast/East and South Asia. Subjects with advanced fibrosis had PRO impairment in 3 CLDQ domains, Activity of WPAI (p < 0.05). HBV subjects with superimposed fatty liver had more PRO impairments. In multivariate analysis adjusted for location, predictors of PRO impairment in CHB included female sex, advanced fibrosis, and non-hepatic comorbidities (p < 0.05). In comparison to Global Liver Registry patients, 242 controls from clinical trials had better PRO scores (Abdominal, Emotional, and Systemic scores of CLDQ, all domains of WPAI) (p < 0.05). In multivariate analysis with adjustment for location and clinicodemographic parameters, the associations of PROs with the enrollment setting (real-life Global Liver Registry vs. clinical trials) were no longer significant (all p > 0.10). The clinico-demographic portrait of CHB patients varies across regions of the world and enrollment settings. Advanced fibrosis and non-hepatic comorbidities are independently associated with PRO impairment in CHB patients. | es_ES |
dc.description.sponsorship | The study was funded by the Center for Outcomes Research in Liver Diseases (COR-LD), Washington, DC, USA. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | John Wiley & Sons | es_ES |
dc.relation.isbasedon | The underlying dataset has been published as supplementary material of the article in the publisher platform at https://doi.org/10.1111/jvh.13800 | es_ES |
dc.rights | closedAccess | es_ES |
dc.subject | Emotional well-being | es_ES |
dc.subject | Fatigue | es_ES |
dc.subject | Fatty liver | es_ES |
dc.subject | Physical functioning | es_ES |
dc.subject | Viral hepatitis | es_ES |
dc.subject | Work productivity | es_ES |
dc.title | Clinical and patient-reported outcome profile of patients with hepatitis B viral infection from the Global Liver Registry™ | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1111/jvh.13800 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1111/jvh.13800 | es_ES |
dc.identifier.e-issn | 1365-2893 | - |
dc.contributor.funder | Center for Outcomes Research in Liver Diseases (US) | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
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