Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/348495
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Novel pharmacological approaches in abdominal aortic aneurysm |
Autor: | Puertas-Umbert, Lídia; Almendra-Pegueros, Rafael; Jiménez-Altayó, Francesc; Sirvent, Marc; Galán, María; Martínez-González, José CSIC ORCID; Rodríguez-Sinovas, Cristina CSIC ORCID | Palabras clave: | Abdominal aortic aneurysm Clinical trials Therapeutic target |
Fecha de publicación: | 14-ago-2023 | Editor: | Biochemical Society Portland Press |
Citación: | Clinical Science 137(15): 1167-1194 (2023) | Resumen: | Abdominal aortic aneurysm (AAA) is a severe vascular disease and a major public health issue with an unmet medical need for therapy. This disease is featured by a progressive dilation of the abdominal aorta, boosted by atherosclerosis, ageing, and smoking as major risk factors. Aneurysm growth increases the risk of aortic rupture, a life-threatening emergency with high mortality rates. Despite the increasing progress in our knowledge about the etiopathology of AAA, an effective pharmacological treatment against this disorder remains elusive and surgical repair is still the unique available therapeutic approach for high-risk patients. Meanwhile, there is no medical alternative for patients with small aneurysms but close surveillance. Clinical trials assessing the efficacy of antihypertensive agents, statins, doxycycline, or anti-platelet drugs, among others, failed to demonstrate a clear benefit limiting AAA growth, while data from ongoing clinical trials addressing the benefit of metformin on aneurysm progression are eagerly awaited. Recent preclinical studies have postulated new therapeutic targets and pharmacological strategies paving the way for the implementation of future clinical studies exploring these novel therapeutic strategies. This review summarises some of the most relevant clinical and preclinical studies in search of new therapeutic approaches for AAA. | Versión del editor: | https://doi.org/10.1042/CS20220795 | URI: | http://hdl.handle.net/10261/348495 | DOI: | 10.1042/CS20220795 | ISSN: | 0143-5221 | E-ISSN: | 1470-8736 |
Aparece en las colecciones: | (IIBB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
cs-2022-0795c.pdf | 2,66 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
2
checked on 21-abr-2024
SCOPUSTM
Citations
3
checked on 22-abr-2024
WEB OF SCIENCETM
Citations
3
checked on 27-feb-2024
Page view(s)
13
checked on 28-abr-2024
Download(s)
6
checked on 28-abr-2024