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Título: | Immune cell kinetics and antibody response in COVID-19 patients with low-count monoclonal B-cell lymphocytosis |
Autor: | Oliva-Ariza, Guillermo; Fuentes-Herrero, Blanca; Lécrevisse, Quentin; Carbonell, Cristina; Pérez-Pons, Alba; Torres-Valle, Alba; Pozo, Julio; Martín-Oterino, José Ángel; González-López, Óscar; López-Bernús, Amparo; Bernal-Ribes, Marta; Belhassen-García, Moncef; Pérez-Escurza, Oihane; Pérez-Andrés, Martin CSIC ORCID CVN; Vázquez, Lourdes; Hernández-Pérez, Guillermo; García Palomo, Francisco Javier; Leoz, Pilar; Costa-Alba, Pilar; Pérez-Losada, Elena; Yeguas, Ana; Santos Sánchez, Miryam; García-Blázquez, Marta; Morán-Plata, F Javier; Damasceno, Daniela; Botafogo, Vitor; Muñoz-García, Noemí; Fluxa, Rafael; Dongen, J. J. M. van; Marcos, Miguel; Almeida, Julia CSIC ORCID CVN; Orfao, Alberto CSIC ORCID | Fecha de publicación: | dic-2023 | Editor: | John Wiley & Sons | Citación: | American Journal of Hematology 98(12): 1909-1922 (2023) | Resumen: | Low-count monoclonal B-cell lymphocytosis (MBLlo) has been associated with an underlying immunodeficiency and has recently emerged as a new risk factor for severe COVID-19. Here, we investigated the kinetics of immune cell and antibody responses in blood during COVID-19 of MBLlo versus non-MBL patients. For this study, we analyzed the kinetics of immune cells in blood of 336 COVID-19 patients (74 MBLlo and 262 non-MBL), who had not been vaccinated against SARS-CoV-2, over a period of 43 weeks since the onset of infection, using high-sensitivity flow cytometry. Plasma levels of anti-SARS-CoV-2 antibodies were measured in parallel by ELISA. Overall, early after the onset of symptoms, MBLlo COVID-19 patients showed increased neutrophil, monocyte, and particularly, plasma cell (PC) counts, whereas eosinophil, dendritic cell, basophil, and lymphocyte counts were markedly decreased in blood of a variable percentage of samples, and with a tendency toward normal levels from week +5 of infection onward. Compared with non-MBL patients, MBLlo COVID-19 patients presented higher neutrophil counts, together with decreased pre-GC B-cell, dendritic cell, and innate-like T-cell counts. Higher PC levels, together with a delayed PC peak and greater plasma levels of anti-SARS-CoV-2-specific antibodies (at week +2 to week +4) were also observed in MBLlo patients. In summary, MBLlo COVID-19 patients share immune profiles previously described for patients with severe SARS-CoV-2 infection, associated with a delayed but more pronounced PC and antibody humoral response once compared with non-MBL patients. | Versión del editor: | https://doi.org/10.1002/ajh.27119 | URI: | http://hdl.handle.net/10261/347521 | DOI: | 10.1002/ajh.27119 | ISSN: | 0361-8609 | E-ISSN: | 1096-8652 |
Aparece en las colecciones: | (IBMCC) Artículos (PTI Salud Global) Colección Especial COVID-19 |
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Immune-cell-kinetics_Oliva_Art2023.pdf | 4,93 MB | Adobe PDF | Visualizar/Abrir |
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