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| Título: | Supplementary Information - ZEB1 hypermethylation is associated with better prognosis in patients with colon cancer |
Autor: | Fernández-De-Los-Reyes, Irene; Gómez-Dorronsoro, Marisa; Monreal-Santesteban, Iñaki; Fernández, Agustín F. CSIC ORCID; Fraga, Mario F. CSIC ORCID; Azcue, Pablo; Alonso, Laura; Fernández-Marlasca, Beatriz; Suárez, Javier; Córdoba-Iturriagagoitia, Alicia; Guerrero-Setas, David | Fecha de publicación: | 2023 | Editor: | BioMed Central Springer Nature |
Citación: | Fernández-De-Los-Reyes, Irene; Gómez-Dorronsoro, Marisa; Monreal-Santesteban, Iñaki; Fernández, Agustín F.; Fraga, Mario F.; Azcue, Pablo; Alonso, Laura; Fernández-Marlasca, Beatriz; Suárez, Javier; Córdoba-Iturriagagoitia, Alicia; Guerrero-Setas, David; 2023; Supplementary Information - ZEB1 hypermethylation is associated with better prognosis in patients with colon cancer [Dataset]; Springer Nature; https://doi.org/10.1186/s13148-023-01605-7 | Descripción: | Additional file 1: Fig. 1. Negative IHC staining for a CDX2 methylated tumor (upper); positive tumor corresponding to an unmethylated CDX2 tumor (lower) in TMA sections (magnification: x400). Additional file 2: Fig. 2. Inhibition of ZEB1 expression in RKO cells by shRNAs_ZEB1_1 and _3. Knockdown efficiency in control and silenced cells was also checked by qRT-PCR (absolute values: 2−ΔCt). (*p<0.05; **p<0.01; ***p<0.001). Additional file 3: Fig. 3. Kaplan–Meier plots for disease-free survival (A) and overall survival (B) stratified by ZEB1 promoter hypermethylation status in the CMS2/3 group of patients. Additional file 4: Fig. 4. Kaplan–Meier Curves for A disease-free survival (DFS) and B overall survival (OS) stratified by CDX2 hypermethylation status; C DFS and D OS stratified by FRMD6 hypomethylation status. Additional file 5: Table 1. Antibodies used for the immunohistochemical analysis. Table 2. Primers and conditions used for bisulfite PCR and pyrosequencing. Table 3. Sequences of shRNAs used for ZEB1 silencing | URI: | http://hdl.handle.net/10261/346539 | DOI: | 10.1186/s13148-023-01605-7 | Referencias: | Fernández-De-Los-Reyes, Irene; Gómez-Dorronsoro, Marisa; Monreal-Santesteban, Iñaki; Fernández, Agustín F.; Fraga, Mario F.; Azcue, Pablo; Alonso, Laura; Fernández-Marlasca, Beatriz; Suárez, Javier; Córdoba-Iturriagagoitia, Alicia; Guerrero-Setas, David. ZEB1 hypermethylation is associated with better prognosis in patients with colon cancer. https://doi.org/10.1186/s13148-023-01605-7. http://hdl.handle.net/10261/346536 |
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