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Título: | The HIV/AIDS vaccine candidate MVA-B administered as a single immunogen in humans triggers robust, polyfunctional, and selective effector memory T cell responses to HIV-1 antigens |
Autor: | Gómez, Carmen E. CSIC ORCID; Nájera, José Luis; Perdiguero, Beatriz; García-Arriaza, Juan CSIC ORCID ; Sorzano, Carlos Oscar S; Jiménez, Victoria; González-Sanz, Rubén; Jiménez, José Luis; Muñoz-Fernández, María Angeles; López Bernaldo de Quirós, Juan Carlos; Guardo, Alberto C; García, Felipe; Gatell, José M; Plana, Montserrat; Esteban, Mariano CSIC ORCID | Fecha de publicación: | nov-2011 | Resumen: | Attenuated poxvirus vectors expressing human immunodeficiency virus type 1 (HIV-1) antigens are considered promising HIV/AIDS vaccine candidates. Here, we describe the nature of T cell immune responses induced in healthy volunteers participating in a phase I clinical trial in Spain after intramuscular administration of three doses of the recombinant MVA-B-expressing monomeric gp120 and the fused Gag-Pol-Nef (GPN) polyprotein of clade B. The majority (92.3%) of the volunteers immunized had a positive specific T cell response at any time postvaccination as detected by gamma interferon (IFN-γ) intracellular cytokine staining (ICS) assay. The CD4(+) T cell responses were predominantly Env directed, whereas the CD8(+) T cell responses were similarly distributed against Env, Gag, and GPN. The proportion of responders after two doses of MVA-B was similar to that obtained after the third dose of MVA-B vaccination, and the responses were sustained (84.6% at week 48). Vaccine-induced CD8(+) T cells to HIV-1 antigens after 1 year were polyfunctional and distributed mainly within the effector memory (TEM) and terminally differentiated effector memory (TEMRA) T cell populations. Antivector T cell responses were mostly induced by CD8(+) T cells, highly polyfunctional, and of TEMRA phenotype. These findings demonstrate that the poxvirus MVA-B vaccine candidate given alone is highly immunogenic, inducing broad, polyfunctional, and long-lasting CD4 and CD8 T cell responses to HIV-1 antigens, with preference for TEM. Thus, on the basis of the immune profile of MVA-B in humans, this immunogen can be considered a promising HIV/AIDS vaccine candidate. | Descripción: | Clinical Trial, Phase I | Versión del editor: | https://doi.org/10.1128/jvi.05165-11 | URI: | http://hdl.handle.net/10261/345733 | DOI: | 10.1128/JVI.05165-11 | ISSN: | 0022538X |
Aparece en las colecciones: | (CNB) Artículos |
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9. J. Virol. 2011. RISVAC02.pdf | 2,06 MB | Adobe PDF | Visualizar/Abrir |
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