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Título: | Dysfunctional serotonergic neuron-astrocyte signaling in depressive-like states |
Autor: | González-Arias, Candela CSIC ORCID; Sanchez-Ruiz, A.; Esparza, Julio CSIC ORCID ; Sánchez-Puelles, Cristina CSIC ; Arancibia, L.; Ramírez-Franco, Jorge CSIC ORCID; Gobbo, D.; Kirchhoff, Frank; Perea, Gertrudis CSIC ORCID | Fecha de publicación: | 2023 | Editor: | Nature Publishing Group | Citación: | Molecular Psychiatry 28: 3856- 3873 (2023) | Resumen: | Astrocytes play crucial roles in brain homeostasis and are regulatory elements of neuronal and synaptic physiology. Astrocytic alterations have been found in Major Depressive Disorder (MDD) patients; however, the consequences of astrocyte Ca signaling in MDD are poorly understood. Here, we found that corticosterone-treated juvenile mice (Cort-mice) showed altered astrocytic Ca dynamics in mPFC both in resting conditions and during social interactions, in line with altered mice behavior. Additionally, Cort-mice displayed reduced serotonin (5-HT)-mediated Ca signaling in mPFC astrocytes, and aberrant 5-HT-driven synaptic plasticity in layer 2/3 mPFC neurons. Downregulation of astrocyte Ca signaling in naïve animals mimicked the synaptic deficits found in Cort-mice. Remarkably, boosting astrocyte Ca signaling with Gq-DREADDS restored to the control levels mood and cognitive abilities in Cort-mice. This study highlights the important role of astrocyte Ca signaling for homeostatic control of brain circuits and behavior, but also reveals its potential therapeutic value for depressive-like states. | Versión del editor: | http://dx.doi.org/10.1038/s41380-023-02269-8 | URI: | http://hdl.handle.net/10261/345597 | Identificadores: | doi: 10.1038/s41380-023-02269-8 issn: 1476-5578 |
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