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http://hdl.handle.net/10261/345281
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Baz-Martínez, Maite | - |
dc.contributor.author | Silva-Alvarez, S. da | - |
dc.contributor.author | Rodríguez, Estefanía | - |
dc.contributor.author | Guerra, Jorge | - |
dc.contributor.author | Motiam, Ahmed El | - |
dc.contributor.author | Vidal, Anxo | - |
dc.contributor.author | García-Caballero, Tomás | - |
dc.contributor.author | González-Barcia, M. | - |
dc.contributor.author | Sánchez, Laura | - |
dc.contributor.author | Muñoz-Fontela, César | - |
dc.contributor.author | Collado, Manuel | - |
dc.contributor.author | Rivas, Carmen | - |
dc.date.accessioned | 2024-02-05T08:53:27Z | - |
dc.date.available | 2024-02-05T08:53:27Z | - |
dc.date.issued | 2016 | - |
dc.identifier | e-issn: 2045-2322 | - |
dc.identifier.citation | Scientific Reports 6: 37007 (2016) | - |
dc.identifier.uri | http://hdl.handle.net/10261/345281 | - |
dc.description.abstract | Cellular senescence is often considered a protection mechanism triggered by conditions that impose cellular stress. Continuous proliferation, DNA damaging agents or activated oncogenes are well-known activators of cell senescence. Apart from a characteristic stable cell cycle arrest, this response also involves a proinflammatory phenotype known as senescence-associated secretory phenotype (SASP). This, together with the widely known interference with senescence pathways by some oncoviruses, had led to the hypothesis that senescence may also be part of the host cell response to fight virus. Here, we evaluate this hypothesis using vesicular stomatitis virus (VSV) as a model. Our results show that VSV replication is significantly impaired in both primary and tumor senescent cells in comparison with non-senescent cells, and independently of the stimulus used to trigger senescence. Importantly, we also demonstrate a protective effect of senescence against VSV in vivo. Finally, our results identify the SASP as the major contributor to the antiviral defense exerted by cell senescence in vitro, and points to a role activating and recruiting the immune system to clear out the infection. Thus, our study indicates that cell senescence has also a role as a natural antiviral defense mechanism. | - |
dc.description.sponsorship | This work was supported by Grant BFU2014- 58530-P from the Ministry of Economy and Competitiveness of Spain and EU-FEDER. MC is a Miguel Servet investigator supported by an ISCIII and EU-FEDER grant (PI14/00554). AEM is a recipient of a FPI predoctoral fellowship from the Ministry of Economy and Competitiveness of Spain. We are grateful to Dr. I Ventoso for providing the anti-VSV-G antibody. | - |
dc.format | application/pdf | - |
dc.language | eng | - |
dc.publisher | Springer Nature | - |
dc.relation | info:eu-repo/grantAgreement/MINECO//BFU2014-58530-P/ES/PAPEL DE SUMO EN LA INTERACCION VIRUS-PI3K%2FAKT/ | - |
dc.relation.isversionof | Publisher's version | - |
dc.subject | Mechanisms of disease | - |
dc.subject | Senescence | - |
dc.title | Cell senescence is an antiviral defense mechanism | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1038/srep37007 | - |
dc.description.peerreviewed | Peer reviewed | - |
dc.relation.publisherversion | http://dx.doi.org/10.1038/srep37007 | - |
dc.date.updated | 2024-02-05T08:53:28Z | - |
dc.rights.holder | openAccess | - |
dc.rights.license | https://creativecommons.org/licenses/by/4.0/ | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Instituto de Salud Carlos III | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.pmid | 27849057 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.openairetype | artículo | - |
Aparece en las colecciones: | (CNB) Artículos |
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Cell_senescence_Baz_Art2016.pdf | 4,54 MB | Adobe PDF | Visualizar/Abrir |
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