Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/344647
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Recognition of peptidoglycan and b-lactam antibiotics by the extracellular domain of the Ser/Thr protein kinase StkP from Streptococcus pneumoniae |
Autor: | Maestro, Beatriz CSIC ORCID; Nováková, Linda; Hesek, Dusan; Lee, Mijoon; Leyva, Eduardo; Mobashery, Shahriar; Sanz, Jesús M. CSIC ORCID CVN ; Branny, P. | Palabras clave: | Signal transduction Penicillin-binding protein and Ser/Thr Protein kinase-associated domain Peptidoglycan B-Lactam antibiotics Protein structure Streptococcus pneumoniae |
Fecha de publicación: | 2011 | Editor: | John Wiley & Sons | Citación: | FEBS Letters 585: 357–363 (2011) | Resumen: | The eukaryotic-type serine/threonine kinase StkP from Streptococcus pneumoniae is an important signal-transduction element that regulates the expression of numerous pneumococcal genes. We have expressed the extracellular C-terminal domain of StkP kinase (C-StkP), elaborated a threedimensional structural model and performed a spectroscopical characterization of its structure and stability. Biophysical experiments show that C-StkP binds to synthetic samples of the cell wall peptidoglycan (PGN) and to b-lactam antibiotics, which mimic the terminal portions of the PGN stem peptide. This is the first experimental report on the recognition of a minimal PGN unit by a PASTAcontaining kinase, suggesting that non-crosslinked PGN may act as a signal for StkP function and pointing to this protein as an interesting target for b-lactam antibiotics. | Descripción: | 29p.-7 fig. | Versión del editor: | https://doi.org/10.1016/j.febslet.2010.12.016 | URI: | http://hdl.handle.net/10261/344647 | DOI: | 10.1016/j.febslet.2010.12.016 | ISSN: | 0014-5793 | E-ISSN: | 1873-3468 |
Aparece en las colecciones: | (CIB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Postprint_Jesus_Sanz_Recognition of peptidoglycan ...(2011).pdf | Postprint | 766,32 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
29
checked on 24-abr-2024
SCOPUSTM
Citations
68
checked on 19-abr-2024
WEB OF SCIENCETM
Citations
65
checked on 23-feb-2024
Page view(s)
13
checked on 27-abr-2024
Download(s)
4
checked on 27-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.