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http://hdl.handle.net/10261/344419
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Garcı́a-Cao, Isabel | es_ES |
dc.contributor.author | Durán Heras, María Ángeles | es_ES |
dc.contributor.author | Collado, Manuel | es_ES |
dc.contributor.author | Carrascosa, María J. | es_ES |
dc.contributor.author | Martín Caballero, Juan | es_ES |
dc.contributor.author | Flores, Juana María | es_ES |
dc.contributor.author | Díaz-Meco, M. Teresa | es_ES |
dc.contributor.author | Moscat, Jorge | es_ES |
dc.contributor.author | Serrano, Manuel | es_ES |
dc.date.accessioned | 2024-01-30T12:20:18Z | - |
dc.date.available | 2024-01-30T12:20:18Z | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | EMBO reports 6(6): 577-583 (2005) | es_ES |
dc.identifier.issn | 1469-221X | - |
dc.identifier.uri | http://hdl.handle.net/10261/344419 | - |
dc.description.abstract | The proapoptotic protein encoded by Par4 (prostate apoptosis response 4) has been implicated in tumour suppression, particularly in the prostate. We report here that Par4‐null mice are prone to develop tumours, both spontaneously and on carcinogenic treatment. The endometrium and prostate of Par4‐null mice were particularly sensitive to the development of proliferative lesions. Most (80%) Par4‐null females presented endometrial hyperplasia by 9 months of age, and a significant proportion (36%) developed endometrial adenocarcinomas after 1 year of age. Similarly, Par4‐null males showed a high incidence of prostate hyperplasia and prostatic intraepithelial neoplasias, and were extraordinarily sensitive to testosterone‐induced prostate hyperplasia. Finally, the uterus and prostate of young Par4‐null mice have increased levels of the apoptosis inhibitor XIAP (X‐chromosome‐linked inhibitor of apoptosis), supporting the previously proposed function of Par4 as an inhibitor of the ζPKC (atypical protein kinase)–NF‐κB (nuclear factor‐κB)–XIAP pathway. These data show that Par4 has an important role in tumour suppression, with a particular relevance in the endometrium and prostate. | es_ES |
dc.description.sponsorship | This work was supported by grants SAF2003‐02613 (to M.T.D.‐M.), SAF2002‐0187 (to J.M.) and SAF2002‐03402 (to M.S.) from the Spanish Ministry of Education and Science, by INTACT (to M.S.) from the European Union and by an institutional grant from Fundación Ramón Areces to the CBMSO. J.M. is the recipient of the Ayuda Investigación Juan March 2001. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | EMBO Press | es_ES |
dc.rights | closedAccess | es_ES |
dc.title | Tumour‐suppression activity of the proapoptotic regulator Par4 | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1038/sj.embor.7400421 | - |
dc.relation.publisherversion | https://doi.org/10.1038/sj.embor.7400421 | es_ES |
dc.identifier.e-issn | 1469-3178 | - |
dc.contributor.funder | Ministerio de Educación y Ciencia (España) | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.contributor.funder | Fundación Ramón Areces | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/100008054 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.pmid | 15877079 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
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