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Título: | Iron oxide nanoparticles with antiviral activity against sars and mers coronavirus |
Otros títulos: | Eisenoxidnanopartikel mit antiviraler wirkung gegen sars- und mers-coronavirus Nanoparticules d'oxyde de fer avec activité antivirale contre le coronavirus sars et mers |
Autor: | Barber, Domingo F. CSIC ORCID ; Morales, M. P. CSIC ORCID ; DeDiego, Marta L. CSIC ORCID ; Mulens-Arias, Vladimir CSIC ORCID ; Portilla, Yadileiny; Daviu, Neus; Veintemillas-Verdaguer, S. CSIC ORCID ; Gallo-Cordova, Álvaro; Villamayor Coronado, Laura CSIC ORCID; López-García, Darío | Fecha de publicación: | 3-may-2023 | Citación: | EP4173617 A1 | Resumen: | Coronaviridae viruses usually cause mild respiratory disease in humans, nevertheless a new infectious disease caused by Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread globally since December 2019, resulting in the ongoing 2019-2021 coronavirus pandemic. The present invention discloses the use of coated iron oxide nanoparticles (IONPs) for use in the treatment and/or prevention of viral infections caused by Coronaviridae, especially those caused by respiratory syndrome-related coronaviruses such as SARS-CoV, SARS-CoV-2 and MERS-CoV. The iron oxide nanoparticles are coated with biocompatible molecules and polymers which bind to the nanoparticle core via oxygen, nitrogen and sulfur donor atoms (e.g. dextran, (3-aminopropyl)triethoxysilane or dimercaptosuccinic acid, respectively). The IONPs were found stable, non-cytotoxic in vitro and can efficiently impair virus replication, transcription and production of infectious virus. Furthermore, the IONPs are suitable for oral, intranasal or parenteral administration in combination with a pharmaceutical carrier. | URI: | http://hdl.handle.net/10261/342748 |
Aparece en las colecciones: | (CNB) Patentes (ICMM) Patentes (PTI Salud Global) Colección Especial COVID-19 |
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EP4173617A1.pdf | 7,01 MB | Adobe PDF | Visualizar/Abrir |
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