Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/340622
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Serum S-100B adds incremental value for the prediction of symptomatic intracranial hemorrhage and brain edema after acute ischemic stroke |
Autor: | Honegger, Tim; Schweizer, Juliane; Bicvic, Antonela; Westphal, Laura P.; Schütz, Valerie; Inauen, Corinne; Pokorny, Thomas; Bracher, Katja; Arnold, Marcel; Fischer, Urs; Bonati, Leo H.; De Marchis, Gian Marco; Nedeltchev, Krassen; Kahles, Timo; Cereda, Carlo W.; Kägi, Georg; Montaner, Joan CSIC ORCID; Bustamante, Alejandro; Palà, Elena; Ntaios, George; Foerch, Christian; Luft, Andreas; Spanaus, Katharina; Saleh, Lanja; Eckardstein, Arnold von; Arnold, Markus; Katan, Mira | Palabras clave: | S-100B Brain edema Intracranial hemorrhage Ischemic stroke Serum biomarker Stroke complications |
Fecha de publicación: | mar-2023 | Editor: | Sage Publications | Citación: | European Stroke Journal 8(1): 309-319 (2023) | Resumen: | [Background] Early identification of patients developing symptomatic intracranial hemorrhage and symptomatic brain edema after acute ischemic stroke is essential for clinical decision-making. Astroglial protein S-100B is a marker of blood-brain barrier disruption, which plays an important role in the formation of intracranial hemorrhage and brain edema. In this study, we assessed the prognostic value of serum S-100B for the development of these complications. [Methods] Serum S-100B levels were measured within 24 h from symptom onset in 1749 consecutive acute ischemic stroke patients from the prospective, observational, multicenter BIOSIGNAL cohort study (mean age 72.0 years, 58.3% male). To determine symptomatic intracranial hemorrhage or symptomatic brain edema, follow-up neuroimaging was performed in all patients receiving reperfusion therapy or experiencing clinical worsening with an NIHSS increase of ⩾4. [Results] Forty six patients (2.6%) developed symptomatic intracranial hemorrhage and 90 patients (5.2%) developed symptomatic brain edema. After adjustment for established risk factors, log10S-100B levels remained independently associated with both symptomatic intracranial hemorrhage (OR 3.41, 95% CI 1.7–6.9, p = 0.001) and symptomatic brain edema (OR 4.08, 95% CI 2.3–7.1, p < 0.001) in multivariable logistic regression models. Adding S-100B to the clinical prediction model increased the AUC from 0.72 to 0.75 (p = 0.001) for symptomatic intracranial hemorrhage and from 0.78 to 0.81 (p < 0.0001) for symptomatic brain edema. [Conclusions] Serum S-100B levels measured within 24 h after symptom onset are independently associated with the development of symptomatic intracranial hemorrhage and symptomatic brain edema in acute ischemic stroke patients. Thus, S-100B may be useful for early risk-stratification regarding stroke complications. |
Versión del editor: | https://doi.org/10.1177/23969873221145391 | URI: | http://hdl.handle.net/10261/340622 | DOI: | 10.1177/23969873221145391 | ISSN: | 2396-9873 | E-ISSN: | 2396-9881 |
Aparece en las colecciones: | (IBIS) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Serum S-100B_Honegger.pdf | 385,45 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
3
checked on 17-may-2024
SCOPUSTM
Citations
4
checked on 16-may-2024
WEB OF SCIENCETM
Citations
2
checked on 28-feb-2024
Page view(s)
30
checked on 22-may-2024
Download(s)
29
checked on 22-may-2024