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http://hdl.handle.net/10261/340206
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dc.contributor.author | Puertas-Umbert, Lídia | es_ES |
dc.contributor.author | Alonso, Judith | es_ES |
dc.contributor.author | Hove-Madsen, Leif | es_ES |
dc.contributor.author | Martínez-González, José | es_ES |
dc.contributor.author | Rodríguez, Cristina | es_ES |
dc.date.accessioned | 2023-12-04T10:18:00Z | - |
dc.date.available | 2023-12-04T10:18:00Z | - |
dc.date.issued | 2023-12-01 | - |
dc.identifier.citation | International Journal of Molecular Sciences 24(23): 17017 (2023) | es_ES |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | http://hdl.handle.net/10261/340206 | - |
dc.description.abstract | 3′,5′-cyclic adenosine monophosphate (cAMP) is a second messenger critically involved in the control of a myriad of processes with significant implications for vascular and cardiac cell function. The temporal and spatial compartmentalization of cAMP is governed by the activity of phosphodiesterases (PDEs), a superfamily of enzymes responsible for the hydrolysis of cyclic nucleotides. Through the fine-tuning of cAMP signaling, PDE4 enzymes could play an important role in cardiac hypertrophy and arrhythmogenesis, while it decisively influences vascular homeostasis through the control of vascular smooth muscle cell proliferation, migration, differentiation and contraction, as well as regulating endothelial permeability, angiogenesis, monocyte/macrophage activation and cardiomyocyte function. This review summarizes the current knowledge and recent advances in understanding the contribution of the PDE4 subfamily to cardiovascular function and underscores the intricate challenges associated with targeting PDE4 enzymes as a therapeutic strategy for the management of cardiovascular diseases. | es_ES |
dc.description.sponsorship | The authors gratefully appreciate the support provided by Instituto de Salud Carlos III (ISCIII; [grant PI21/01048]) and Spanish Ministerio de Ciencia e Innovación (Grant PID2021-122509OB-I00 funded by MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe”). We thank the support provided by Fundación Española de Arteriosclerosis (FEA-2020). L.P-U. was supported by a PFIS fellowship (ISCIII). | es_ES |
dc.format | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Multidisciplinary Digital Publishing Institute | es_ES |
dc.relation | info:eu-repo/grantAgreement/AEI//PID2021-122509OB-I00 | es_ES |
dc.relation.isversionof | Publisher's version | es_ES |
dc.relation.isbasedon | The underlying dataset has been published as supplementary material of the article in the publisher platform at https://doi.org/10.3390/ijms242317017 | - |
dc.rights | openAccess | es_ES |
dc.subject | PDE4 | es_ES |
dc.subject | Cardiovascular diseases | es_ES |
dc.subject | Therapy | es_ES |
dc.title | PDE4 Phosphodiesterases in Cardiovascular Diseases: Key Pathophysiological Players and Potential Therapeutic Targets | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.3390/ijms242317017 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.3390/ijms242317017 | es_ES |
dc.identifier.e-issn | 1422-0067 | - |
dc.date.updated | 2023-12-04T10:18:00Z | - |
dc.rights.license | http://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.contributor.funder | Agencia Estatal de Investigación (España) | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.contributor.funder | Sociedad Española de Arteriosclerosis | es_ES |
dc.relation.csic | Sí | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011033 | es_ES |
dc.contributor.orcid | Hove-Madsen, Leif [0000-0001-5493-3998] | es_ES |
dc.contributor.orcid | Martínez-González, José [0000-0002-3894-7166] | es_ES |
dc.contributor.orcid | Rodríguez, Cristina [0000-0002-6472-5647] | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.languageiso639-1 | en | - |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
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