Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/338719
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | TRPA1 channels: molecular sentinels of cellular stress and tissue damage |
Autor: | Viana, Félix CSIC ORCID | Fecha de publicación: | 2016 | Editor: | Wiley-VCH | Citación: | Journal of Physiology 594: 4151-4169 (2016) | Resumen: | TRPA1 is a non‐selective cation channel expressed in mammalian peripheral pain receptors, with a major role in chemonociception. TRPA1 has also been implicated in noxious cold and mechanical pain sensation. TRPA1 has an ancient origin and plays important functions in lower organisms, including thermotaxis, mechanotransduction and modulation of lifespan. Here we highlight the role of TRPA1 as a multipurpose sensor of harmful signals, including toxic bacterial products and UV light, and as a sensor of stress and tissue damage. Sensing roles span beyond the peripheral nervous system to include major barrier tissues: gut, skin and lung. Tissue injury, environmental irritants and microbial pathogens are danger signals that can threaten the health of organisms. These signals lead to the coordinated activation of the nociceptive and the innate immune system to provide a homeostatic response trying to re‐establish physiological conditions including tissue repair. Activation of TRPA1 participates in protective neuroimmune interactions at multiple levels, sensing ROS and bacterial products and triggering the release of neuropeptides. However, an exaggerated response to danger signals is maladaptive and can lead to the development of chronic inflammatory conditions. | Descripción: | This review was presented at the symposium “Non-selective cationic channels in chemical and physical stress?”, which took place at Physiology 2015in Cardiff, UK, 6–8 July 2015. | Versión del editor: | https://doi.org/10.1113/JP270935 | URI: | http://hdl.handle.net/10261/338719 | DOI: | 10.1113/JP270935 | E-ISSN: | 1469-7793 |
Aparece en las colecciones: | (IN) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 59,24 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
82
checked on 01-may-2024
SCOPUSTM
Citations
139
checked on 14-may-2024
WEB OF SCIENCETM
Citations
129
checked on 29-feb-2024
Page view(s)
18
checked on 16-may-2024
Download(s)
4
checked on 16-may-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.