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Título: | The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity |
Autor: | Alonso De Diego, Sergio A. CSIC; Gutiérrez-Rodríguez, Marta CSIC ORCID ; Pérez de Vega, M. Jesús CSIC ORCID; González-Muñiz, Rosario CSIC ORCID; Herranz, Rosario CSIC ORCID; Martín-Martínez, Mercedes CSIC ORCID; Cenarruzabeitia, Edurne CSIC; Frechilla, Diana; Río, Joaquín del CSIC; Jimeno, M. Luisa CSIC ORCID; García-López, M. Teresa CSIC | Palabras clave: | Neuroprotection Glutamate receptors binding Tripeptides Peptidomimetics GPE |
Fecha de publicación: | 1-jul-2006 | Editor: | Elsevier | Citación: | Bioorganic & Medicinal Chemistry Letters 16(13): 3396-3400 (2006) | Resumen: | The influence of several modifications on the GPE tripeptide structure upon the binding to GluRs and on their neuroprotective effects has been studied. The results indicated that the prevention of neuronal death showed by GPE and some analogues is not directly related to their affinity at glutamate receptors. | Versión del editor: | http://dx.doi.org/10.1016/j.bmcl.2006.04.033 | URI: | http://hdl.handle.net/10261/33631 | DOI: | 10.1016/j.bmcl.2006.04.033 | ISSN: | 0960-894X |
Aparece en las colecciones: | (IQM) Artículos |
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