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| Título: | New conformationally constrained tryptophans by N(α)-C(α)-cyclization to an azetidin-2-one core |
Autor: | Gerona-Navarro, Guillermo CSIC; Bonache de Marcos, María Ángeles CSIC ORCID; Herranz, Rosario CSIC ORCID; García-López, M. Teresa CSIC ; González-Muñiz, Rosario CSIC ORCID | Palabras clave: | Azetidines/azetidin-2-ones Chemoselective reduction Constrained amino acids Intramolecular alkylation |
Fecha de publicación: | 2000 | Editor: | Thieme | Citación: | Synlett 9: 1249-1252 (2000) | Resumen: | An entry to new conformationally restricted tryptophans, obtained through N(α)-C(α)-cyclization to an azetidin-2-one core, is described. The yield and ratio of β-lactamization from N(α)-chloroacetyl tryptophan derivatives were dependent on the base and the solvent used. The chemoselective reduction of the β-lactam ring to the corresponding azetidine is also described. | URI: | http://hdl.handle.net/10261/336317 | ISSN: | 0936-5214 | E-ISSN: | 1437-2096 |
| Aparece en las colecciones: | (IQM) Artículos |
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| accesoRestringido.pdf | 15,38 kB | Adobe PDF |  Visualizar/Abrir |
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