Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/336251
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Immune evasion through toll-like receptor 4: the role of the core oligosaccharides from α2-proteobacteria atypical lipopolysaccharides |
Autor: | Matamoros-Recio, Alejandra CSIC ORCID; Merino, Javier CSIC; Gallego-Jiménez, Alicia; Conde-Álvarez, Raquel; Fresno, Manuel CSIC ORCID ; Martín-Santamaría, Sonsoles CSIC ORCID | Palabras clave: | Toll-like receptor 4 Atypical lipopolysaccharides Immuno-evasion Molecular modeling Computational simulations |
Fecha de publicación: | 15-oct-2023 | Editor: | Elsevier | Citación: | Carbohydrate Polymers 318: 121094 ( 2023) | Resumen: | Lipopolysaccharides (LPS) are major players in bacterial infection through the recognition by Toll-like receptor 4 (TLR4). The LPS chemical structure, including the oligosaccharide core and the lipid A moiety, can be strongly influenced by adaptation and modulated to assure bacteria protection, evade immune surveillance, or reduce host immune responses. Deep structural understanding of TLRs signaling is essential for the modulation of the innate immune system in sepsis control and inflammation, during bacterial infection. To advance this knowledge, we have employed computational techniques to characterize the TLR4 molecular recognition of atypical LPSs from different opportunistic members of α2-Proteobacteria, including Brucella melitensis, Ochrobactrum anthropi, and Ochrobactrum intermedium, with diverse immunostimulatory activities. We contribute to unraveling the role of uncommon lipid A chemical features such as bearing very long-chain fatty acid chains, whose presence has been rarely reported, on modulating the proper heterodimerization of the TLR4 receptor complex. Moreover, we further evaluated the influence of the different oligosaccharide cores, including sugar composition and net charge, on TLR4 activation. Our studies contribute to elucidating, from the molecular and biological perspectives, the impact of the α2-Proteobacteria LPS cores and the chemical structure of the atypical lipid A for immune system evasion in opportunistic bacteria. | Descripción: | 15 p.-10 fig. | Versión del editor: | https://doi.org/10.1016/j.carbpol.2023.121094 | URI: | http://hdl.handle.net/10261/336251 | DOI: | 10.1016/j.carbpol.2023.121094 | ISSN: | 0144-8617 | E-ISSN: | 1879-1344 |
Aparece en las colecciones: | (CIB) Artículos (CBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Carbohydrate Polymers_Matamoros-Recio_2023.pdf | 16,96 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
5
checked on 11-may-2024
WEB OF SCIENCETM
Citations
1
checked on 19-feb-2024
Page view(s)
38
checked on 16-may-2024
Download(s)
8
checked on 16-may-2024
Google ScholarTM
Check
Altmetric
Altmetric
Este item está licenciado bajo una Licencia Creative Commons