Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/335661
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Dakir, El Habib | es_ES |
dc.contributor.author | Gajate, Consuelo | es_ES |
dc.contributor.author | Mollinedo, Faustino | es_ES |
dc.date.accessioned | 2023-09-25T10:39:59Z | - |
dc.date.available | 2023-09-25T10:39:59Z | - |
dc.date.issued | 2023-11 | - |
dc.identifier.citation | Biomedicine and Pharmacotherapy 167: 115436 (2023) | es_ES |
dc.identifier.issn | 0753-3322 | - |
dc.identifier.uri | http://hdl.handle.net/10261/335661 | - |
dc.description | 11 p.-5 fig. | es_ES |
dc.description.abstract | Prostate cancer is the second most frequent cancer and the fifth leading cause of cancer death among men worldwide. While the five-year survival in local and regional prostate cancer is higher than 99%, it falls to about 28% in advanced metastatic prostate cancer. The ether lipid edelfosine is considered the prototype of a family of promising antitumor drugs collectively named as alkylphospholipid analogs. Here, we found that edelfosine was the most potent alkylphospholipid analog in inducing apoptosis in three different human prostate cancer cell lines (LNCaP, PC3, and DU145) with distinct androgen dependency, and differing in tumor suppressor phosphatase and tensin homolog (PTEN) and p53 status. Edelfosine accumulated in the endoplasmic reticulum of prostate cancer cells, leading to endoplasmic reticulum stress and cell death in the three prostate cancer cells. Inhibition of autophagy potentiated the pro-apoptotic activity of edelfosine in LNCaP and PC3 cells, where autophagy was induced as a survival response. Edelfosine induced a slight and transient inhibition of AKT in PTEN-negative LNCaP and PC3 cells, but not in PTEN-positive DU145 cells. Daily oral administration of edelfosine in murine prostate restricted AKT kinase transgenic mice, expressing active AKT in a prostate-specific manner, and in a DU145 xenograft mouse model resulted in significant tumor regression and apoptosis in tumor cells. Taken together, these results show a significant in vitro and in vivo antitumor activity of edelfosine against prostate cancer, and highlight the endoplasmic reticulum as a novel and promising therapeutic target in prostate cancer. | es_ES |
dc.description.sponsorship | This work was supported by grant PID2020-119656RB-I00 funded by MCIN/AEI/10.13039/501100011033 from the Spanish Ministry of Science and Innovation (Agencia Estatal de Investigación), as well as by grants from the Spanish Ministry of Science, Innovation and Universities (SAF2017-89672-R, and SAF2014-59716-R). | es_ES |
dc.language.iso | spa | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-119656RB-I00/ES/PLASTICIDAD DE NEUTROFILOS Y LIPID RAFTS EN LA METASTASIS Y TERAPIA DEL CANCER: DIANAS VERSATILES EN DESCUBRIMIENTO DE FARMACOS Y PARTICIPACION DE ANALOGOS ALQUILFOSFOLIPIDOS/ | es_ES |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-89672-R/ES/LIPID RAFTS Y ENTORNO TUMORAL INFLAMATORIO EN LA TERAPIA DEL CANCER: ANALOGOS ALQUILFOSFOLIPIDOS COMO AGENTES DIRIGIDOS FRENTE A LIPID RAFTS E INFLAMACION/ | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO//SAF2014-59716-R/ES/LIPID RAFTS, CANCER STEM CELLS Y MICROENTORNO TUMORAL INFLAMATORIO EN LA TERAPIA DEL CANCER: ANALOGOS ALQUILFOSFOLIPIDOS COMO AGENTES LIDER EN TERAPIAS DIRIGIDAS A LIPID RAFTS/ | es_ES |
dc.relation.isversionof | Publisher's version | es_ES |
dc.relation.isbasedon | The underlying dataset has been published as supplementary material of the article in the publisher platform at 10.1016/j.biopha.2023.115436 | - |
dc.rights | openAccess | es_ES |
dc.subject | Edelfosine | es_ES |
dc.subject | Alkylphospholipid analog | es_ES |
dc.subject | MPAKT transgenic animal model | es_ES |
dc.subject | Xenograft animal model | es_ES |
dc.subject | Endoplasmic reticulum | es_ES |
dc.subject | Prostate cancer | es_ES |
dc.title | Antitumor activity of alkylphospholipid edelfosine in prostate cancer models and endoplasmic reticulum targeting | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1016/j.biopha.2023.115436 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.biopha.2023.115436 | es_ES |
dc.rights.license | https://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.contributor.funder | Agencia Estatal de Investigación (España) | es_ES |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011033 | es_ES |
dc.contributor.orcid | Dakir, El Habib [0000-0002-8482-3412] | es_ES |
dc.contributor.orcid | Gajate, Consuelo [0000-0003-0604-6459] | es_ES |
dc.contributor.orcid | Mollinedo, Faustino [0000-0002-4939-2434] | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | es | - |
item.openairetype | artículo | - |
Aparece en las colecciones: | (CIB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Biomedicine and Pharmacoptherapy_Dakir_2023.pdf | Artículo principal | 4,93 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
2
checked on 12-may-2024
WEB OF SCIENCETM
Citations
1
checked on 25-feb-2024
Page view(s)
34
checked on 29-may-2024
Download(s)
24
checked on 29-may-2024
Google ScholarTM
Check
Altmetric
Altmetric
Este item está licenciado bajo una Licencia Creative Commons