Synthesis of alkylamino derivatives of 1,4,6,11-tetrahydropyridazino[1,2-b]phthalazine-6,11-dione

Abstract

The synthesis of 7-[(3-N,N-dimethylamino)propylamino]-1,4,6,11-tetrahydropyridazino[1,2 -b]phthalazine-6,11-dione derivatives is reported. The expected monoalkylamino substituted derivative (4a) was obtained from the 7-chloro-substituted compound (3a), whereas the 7,10-dichloro-substituted compound (3b) gave a mixture of the monoalkylamino derivative (4b) and the dialkylaminophthalimide (4c). The cytotoxic activity of 4a-c against HeLa cells was assayed. Compounds 4a and 4b showed a higher cytotoxicity than the starting adducts (3a and 3b).