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Título: | Mitophagy in the retina: Viewing mitochondrial homeostasis through a new lens |
Autor: | Jiménez-Loygorri, Juan Ignacio CSIC ORCID; Benítez-Fernández, Rocío CSIC ORCID; Viedma-Poyatos, Álvaro CSIC ORCID ; Zapata-Muñoz, Juan CSIC ORCID; Villarejo-Zori, Beatriz CSIC ORCID ; Gómez-Sintes, Raquel CSIC ORCID ; Boya, Patricia CSIC ORCID | Palabras clave: | Mitophagy Mitochondria Retinal homeostasis Metabolism Autophagy Retinal development Glaucoma Diabetic retinopathy Retinitis pigmentosa Age-related macular degeneration |
Fecha de publicación: | sep-2023 | Editor: | Elsevier | Citación: | Progress in Retinal and Eye Research 96: 101205 (2023) | Resumen: | Mitochondrial function is key to support metabolism and homeostasis in the retina, an organ that has one of the highest metabolic rates body-wide and is constantly exposed to photooxidative damage and external stressors. Mitophagy is the selective autophagic degradation of mitochondria within lysosomes, and can be triggered by distinct stimuli such as mitochondrial damage or hypoxia. Here, we review the importance of mitophagy in retinal physiology and pathology. In the developing retina, mitophagy is essential for metabolic reprogramming and differentiation of retina ganglion cells (RGCs). In basal conditions, mitophagy acts as a quality control mechanism, maintaining a healthy mitochondrial pool to meet cellular demands. We summarize the different autophagy- and mitophagy-deficient mouse models described in the literature, and discuss the potential role of mitophagy dysregulation in retinal diseases such as glaucoma, diabetic retinopathy, retinitis pigmentosa, and age-related macular degeneration. Finally, we provide an overview of methods used to monitor mitophagy in vitro, ex vivo, and in vivo. This review highlights the important role of mitophagy in sustaining visual function, and its potential as a putative therapeutic target for retinal and other diseases. | Descripción: | 27 p.-6 fig.-6 tab. | Versión del editor: | https://doi.org/10.1016/j.preteyeres.2023.101205 | URI: | http://hdl.handle.net/10261/332075 | DOI: | 10.1016/j.preteyeres.2023.101205 | ISSN: | 1350-9462 | E-ISSN: | 1873-1635 |
Aparece en las colecciones: | (CIB) Artículos |
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Progress in Retinal and Eye Research_Jiménez-Loygorri_2023.pdf | Artículo principal | 10,74 MB | Adobe PDF | Visualizar/Abrir |
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