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| Título: | Additional file 1 of Altered methylation pattern in EXOC4 is associated with stroke outcome: an epigenome-wide association study |
Autor: | Cullell, Nàtalia; Soriano-Tárraga, Carolina; Gallego-Fabrega, Cristina; Cárcel-Márquez, Jara; Muiño, Elena; Llucià-Carol, Laia CSIC ORCID; Lledós, Miquel; Esteller, Manel; Moura, Manuel Castro de; Montaner, Joan CSIC ORCID; Rosell, Anna; Delgado, Pilar CSIC ORCID; Marti-Fabregas, Joan; Krupinski, Jerzy; Roquer, Jaume; Jiménez-Conde, Jordi; Fernández-Cadenas, Israel | Palabras clave: | Nominal cpg sites Fixed effect model Nine plasma proteins Measured rna expression Wide significant association Wide association study Conclusions dna methylation Altered methylation pattern Ischaemic stroke patients Health stroke scale Pathways involving endocytosis Assessed using epidish Worse neurological course DNA methylation data Blood also revealed nk cells regulation Metabolic pathway enrichment Type methylation analysis Type methylation Neurological course Methylation data nk cells Analysis revealed Pathway enrichment Pathway analysis Neurological changes Differential methylation Also evaluated Stroke outcome exoc4 expression Term outcome Tendency towards Proteins showed Potential modulation p value Natural killer National institutes Highly variable Heritable factors Genetic factors exoc4 methylation Epic beadchip Edifferentially expressed Deubiquitination processes |
Fecha de publicación: | 1-oct-2022 | Editor: | Figshare | Citación: | Cullell, Nàtalia; Soriano-Tárraga, Carolina; Gallego-Fabrega, Cristina; Cárcel-Márquez, Jara; Muiño, Elena; Llucià-Carol, Laia; Lledós, Miquel; Esteller, Manel; Moura, Manuel Castro de; Montaner, Joan; Rosell, Anna; Delgado, Pilar; Marti-Fabregas, Joan; Krupinski, Jerzy; Roquer, Jaume; Jiménez-Conde, Jordi; Fernández-Cadenas, Israel; 2022; Additional file 1 of Altered methylation pattern in EXOC4 is associated with stroke outcome: an epigenome-wide association study [Dataset]; Figshare; https://doi.org/10.6084/m9.figshare.21256872.v1 | Descripción: | 1-Supplemental Materials and Methods. 2- Supplemental e-FIGURES. Figure I: Workflow for CpG-sites and sample QCs. Figure II: Batch effect evaluation with MDS and SVD plots. Figure III: Manhattan plots for DMCT. Figure IV: cg00039070 methylation correlation between blood and brain. Figure V: Blood–Brain Epigenetic Concordance (BECon) results for cg00039070. 3- Supplemental e-TABLES. Table I: Analysis of variables associated with ∆NIHSS in bivariate and regression analysis. Table II: Analysis of variables associated with mRS at 3 months in bivariate and regression analysis. Table III: Summary statistics for the discovery EWAS adjusted by batch. Table IV: Feature enrichment analysis. Table V: Differentially methylated region (DMR) results. Table VI: Differentially methylated block (DMB) results. Table VII: EWAS summary statistics in the meta-analyses for dichotomic ∆NIHSS. Table VIII: Demographic and clinical data for the subjects included in the analysis with SOMAscan. Table IX: eFORGE analysis. 4- Supplemental References. | Versión del editor: | https://doi.org/10.6084/m9.figshare.21256872.v1 | URI: | http://hdl.handle.net/10261/331080 | DOI: | 10.6084/m9.figshare.21256872.v1 | Referencias: | Cullell, Nàtalia; Soriano-Tárraga, Carolina; Gallego-Fabrega, Cristina; Cárcel-Márquez, Jara; Muiño, Elena; Llucià-Carol, Laia; Lledós, Miquel; Esteller, Manel; Moura, Manuel Castro de; Montaner, Joan; Rosell, Anna; Delgado, Pilar; Marti-Fabregas, Joan; Krupinski, Jerzy; Roquer, Jaume; Jiménez-Conde, Jordi; Fernández-Cadenas, Israel. Altered methylation pattern in EXOC4 is associated with stroke outcome: an epigenome-wide association study. https://doi.org/10.1186/s13148-022-01340-5 . http://hdl.handle.net/10261/289796 |
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| Fichero | Descripción | Tamaño | Formato | |
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| Additional-file_1_EXOC4.docx | 205,19 kB | Microsoft Word XML | Visualizar/Abrir | |
| README.txt | 3,54 kB | Text | Visualizar/Abrir |
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