Supplementary Materials for Lipid nanoparticles for oligonucleotide delivery into brain border-associated macrophages to silence neuroinflammation-related genes

Calero, Macarena; Moleiro, Lara H.; Sayd, Aline; Dorca, Yeray; Miquel-Rio, Lluís; Paz, Verónica; Robledo-Montaña, Javier; Enciso, Eduardo; Acción, Fernando; Herráez-Aguilar, Diego; Hellweg, Thomas; Sánchez, Luis; Bortolozzi, Analía; Leza, Juan C.; García-Bueno, Borja; Monroy, Francisco

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Título:	Supplementary Materials for Lipid nanoparticles for oligonucleotide delivery into brain border-associated macrophages to silence neuroinflammation-related genes
Autor:	Calero, Macarena; Moleiro, Lara H.; Sayd, Aline; Dorca, Yeray; Miquel-Rio, Lluís CSIC ORCID; Paz, Verónica CSIC ORCID; Robledo-Montaña, Javier; Enciso, Eduardo; Acción, Fernando; Herráez-Aguilar, Diego; Hellweg, Thomas; Sánchez, Luis; Bortolozzi, Analía CSIC ORCID; Leza, Juan C.; García-Bueno, Borja; Monroy, Francisco
Fecha de publicación:	2022
Editor:	Frontiers Media
Citación:	Calero, Macarena; Moleiro, Lara H.; Sayd, Aline; Dorca, Yeray; Miquel-Rio, Lluís; Paz, Verónica; Robledo-Montaña, Javier; Enciso, Eduardo; Acción, Fernando; Herráez-Aguilar, Diego; Hellweg, Thomas; Sánchez, Luis; Bortolozzi, Analía; Leza, Juan C.; García-Bueno, Borja; Monroy, Francisco; 2022; Supplementary Materials for Lipid nanoparticles for oligonucleotide delivery into brain border-associated macrophages to silence neuroinflammation-related genes [Dataset]; Frontiers Media; http://dx.doi.org/10.3389/fmolb.2022.887678
Descripción:	Supplementary Figure S1. Stability control by 1H-NMR spectroscopy check for covalent stability in the synthetized compound DSPE-PEG-MAN as obtained by click-chemistry mannosylation of the succinimide ligand DSPE-PE-NHS. Supplementary Figure S2A. Catalogue of GapmeR-based lipid nanoparticles (GR@LNPs). Type A) Compact GR-DChol archetype; Type B) Stratified core-shell population Supplementary Figure S2B. GR@LNPs’ catalogue (cont.). Type C) Hollow, non-complexed with GapmeR @LNPs Supplementary Figure S3. Ultrastructural analysis of the TEM images in terms of the inhomogenous lamellar structure factor. Supplementary Table T1. Best fit parameters from TEM-ultrastructural analysis performed in terms of the inhomogenous lamellar structure factor.
Versión del editor:	http://dx.doi.org/10.3389/fmolb.2022.887678
URI:	http://hdl.handle.net/10261/330045
DOI:	10.3389/fmolb.2022.887678
Referencias:	Calero, Macarena; Moleiro, Lara H.; Sayd, Aline; Dorca, Yeray; Miquel-Rio, Lluís; Paz, Verónica; Robledo-Montaña, Javier; Enciso, Eduardo; Acción, Fernando; Herráez-Aguilar, Diego; Hellweg, Thomas; Sánchez, Luis; Bortolozzi, Analía; Leza, Juan C.; García-Bueno, Borja; Monroy, Francisco. Lipid nanoparticles for oligonucleotide delivery into brain border-associated macrophages to silence neuroinflammation-related genes. http://dx.doi.org/10.3389/fmolb.2022.887678. http://hdl.handle.net/10261/304318
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