Additional file 5 of Overexpression of wild type RRAS2, without oncogenic mutations, drives chronic lymphocytic leukemia [Dataset]

Hortal, Alejandro; Oeste, Clara L.; Cifuentes, Claudia; Alcoceba, Miguel; Fernández-Pisonero, Isabel; Clavaín, Laura; Tercero, Rut; Mendoza, Pilar; Domínguez, Verónica; García-Flores, Marta; Pintado, Belén; Abia, David; García-Macías, Carmen; Navarro-Bailón, Almudena; Bustelo, Xosé R.; González, Marcos; Alarcón, Balbino

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Título:	Additional file 5 of Overexpression of wild type RRAS2, without oncogenic mutations, drives chronic lymphocytic leukemia [Dataset]
Autor:	Hortal, Alejandro; Oeste, Clara L. CSIC ORCID; Cifuentes, Claudia; Alcoceba, Miguel; Fernández-Pisonero, Isabel CSIC ORCID; Clavaín, Laura; Tercero, Rut; Mendoza, Pilar; Domínguez, Verónica; García-Flores, Marta CSIC ; Pintado, Belén; Abia, David CSIC ORCID ; García-Macías, Carmen CSIC ORCID CVN; Navarro-Bailón, Almudena; Bustelo, Xosé R. CSIC ORCID ; González, Marcos CSIC ORCID ; Alarcón, Balbino CSIC ORCID
Palabras clave:	RRAS2 RAS proteins B cells Lymphoid malignancies Chronic lymphocytic leukemia B cell receptor PI3K pathway
Fecha de publicación:	5-feb-2022
Editor:	Figshare
Citación:	Hortal, Alejandro; Oeste, Clara L; Cifuentes, Claudia; Alcoceba, Miguel; Fernández-Pisonero, Isabel; Clavaín, Laura; Tercero, Rut; Mendoza, Pilar; Domínguez, Verónica; García-Flores, Marta; Pintado, Belén; Abia, David; García-Macías, Carmen; Navarro-Bailón, Almudena; Bustelo, Xosé R.; González, Marcos; Alarcón, Balbino; 2022; Additional file 5 of Overexpression of wild type RRAS2, without oncogenic mutations, drives chronic lymphocytic leukemia [Dataset]; Figshare; https://doi.org/10.6084/m9.figshare.19126437.v1
Resumen:	Additional file 5: Figure S5. a, Principal component analysis of CD19 + CD21-CD23+ follicular B cells from Rosa26-RRAS2xmb1-Cre mice, CD19 + CD21-CD23+ follicular B cells from WT C57BL/6 J mice and of leukemic CD19 + CD5+, GFPlow and GFPhigh cells from Rosa26-RRAS2xmb1-Cre mice. b, Ingenuity Pathway Analysis (IPA) of differentially expressed genes associated with molecular mechanisms of cancer in leukemic versus normal follicular B cells. Pink-filled symbols: upregulated genes. Green-filled: downregulated genes. Double circle: protein complex; horizontal ellipse: transcription regulator; vertical ellipse: transmembrane receptor, diamond: enzyme; trapezium: transporter; triangle: phosphatase; inverted triangle: kinase; vertical rectangle: G protein-coupled receptor; circle: other. Black arrows: direct interactions; grey/white arrows: indirect interactions. Relationship labels: A: activation; B: binding; C: causation; CO: correlation; E: expression; EC: enzyme catalysis; I: inhibition; L: molecular cleavage; LO: localization; M: biochemical modification; miT: microRNA Targeting; P: phosphorylation/dephosphorylation; PD: protein-DNA binding; PP: protein-protein binding; PR: protein-RNA binding, RB: regulation of binding; RE: reaction; T: transcription; TR: translocation; UB: ubiquitination.
Versión del editor:	https://doi.org/10.6084/m9.figshare.19126437.v1
URI:	http://hdl.handle.net/10261/329851
DOI:	10.6084/m9.figshare.19126437.v1
Referencias:	Additional file 5: Figure S5. a, Principal component analysis of CD19 + CD21-CD23+ follicular B cells from Rosa26-RRAS2xmb1-Cre mice, CD19 + CD21-CD23+ follicular B cells from WT C57BL/6 J mice and of leukemic CD19 + CD5+, GFPlow and GFPhigh cells from Rosa26-RRAS2xmb1-Cre mice. b, Ingenuity Pathway Analysis (IPA) of differentially expressed genes associated with molecular mechanisms of cancer in leukemic versus normal follicular B cells. Pink-filled symbols: upregulated genes. Green-filled: downregulated genes. Double circle: protein complex; horizontal ellipse: transcription regulator; vertical ellipse: transmembrane receptor, diamond: enzyme; trapezium: transporter; triangle: phosphatase; inverted triangle: kinase; vertical rectangle: G protein-coupled receptor; circle: other. Black arrows: direct interactions; grey/white arrows: indirect interactions. Relationship labels: A: activation; B: binding; C: causation; CO: correlation; E: expression; EC: enzyme catalysis; I: inhibition; L: molecular cleavage; LO: localization; M: biochemical modification; miT: microRNA Targeting; P: phosphorylation/dephosphorylation; PD: protein-DNA binding; PP: protein-protein binding; PR: protein-RNA binding, RB: regulation of binding; RE: reaction; T: transcription; TR: translocation; UB: ubiquitination.
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