Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/315185
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Short-term exposure to pharmaceuticals negatively impacts marine flatfish species: Histological, biochemical and molecular clues for an integrated ecosystem risk assessment |
Autor: | Pess, Katia; Ortiz-Delgado, Juan B. CSIC ORCID ; Sarasquete, Carmen CSIC ORCID ; Laizé, Vincent; Fernández, Ignacio CSIC ORCID | Palabras clave: | Acuicultura Centro Oceanográfico de Vigo Aquatic toxicology warfarin dexamethasone imidazole vertebrates Fish Gene expression antioxidant enzyme activity |
Fecha de publicación: | 29-ene-2022 | Editor: | Elsevier | Citación: | Environmental Toxicology and Pharmacology 90 : 103822 (2022) | Resumen: | The marine habitat and its biodiversity can be impacted by released pharmaceuticals. The short-term (7 days) effect of 3 commonly used drugs – warfarin, dexamethasone and imidazole – on Senegalese sole (Solea senegalensis) juveniles was investigated. Occurrence of hemorrhages, histopathological alterations, antioxidant status, activity of antioxidant enzymes and expression of genes involved in the xenobiotic response (pxr, abcb1 and cyp1a), were evaluated. The results showed a time and drug-dependent effect. Warfarin exposure induced hemorrhages, hepatocyte vacuolar degeneration, and altered the activity of glutathione peroxidase (GPx) and the expression of all the studied genes. Dexamethasone exposure increased liver glycogen content, altered antioxidant status, GPx and superoxide dismutase activities, as well as abcb1 and cyp1a expression. Imidazole induced hepatocyte vacuolar degeneration and ballooning, and altered the antioxidant status and expression of the tested genes. The present work anticipates a deeper impact of pharmaceuticals on the aquatic environment than previously reported, thus underlining the urgent need for an integrated risk assessment. | Versión del editor: | https://doi.org/10.1016/j.etap.2022.103822 | URI: | http://hdl.handle.net/10261/315185 | DOI: | 10.1016/j.etap.2022.103822 | ISSN: | 1382-6689 | E-ISSN: | 1872-7077 |
Aparece en las colecciones: | (IEO) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Pess et al., 2022. Short-term exposure to pharmaceuticals.pdf | 6,13 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
Page view(s)
28
checked on 29-abr-2024
Download(s)
7
checked on 29-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Este item está licenciado bajo una Licencia Creative Commons