Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/309231
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Gimenez-Molina, Yolanda | es_ES |
dc.contributor.author | Villanueva, José | es_ES |
dc.contributor.author | Francés, María del Mar | es_ES |
dc.contributor.author | Viniegra, Salvador | es_ES |
dc.contributor.author | Gutiérrez, Luis M. | es_ES |
dc.date.accessioned | 2023-05-19T09:27:24Z | - |
dc.date.available | 2023-05-19T09:27:24Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Frontiers in Cellular Neuroscience 12: 344 (2018) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10261/309231 | - |
dc.description.abstract | Neuroendocrine chromaffin cells represent an excellent model to study the molecular mechanisms associated with the exo-endocytotic cycle of neurotransmitter release. In this study, EGFP-Lifeact and confocal microscopy has been used to analyze the re-organization of the cortical F-actin cytoskeleton associated to organelle transport during secretion with unprecedented detail. In these cells secretory events accumulate in temperature-sensitive and myosin II-dependent F-actin expansions and retractions affecting specific regions of the sub-membrane space. Interestingly, not only vesicles but also mitochondria are transported toward the plasmalemma during these expansions. Simultaneously, we found F-actin cytoskeletal retraction withdraws vesicles from the sub-plasmalemmal space, forming novel empty internal spaces into which organelles can be transported. In addition to these well-coordinated, F-actin-myosin II dependent processes that drive the transport of the majority of vesicles, fast transport of chromaffin vesicles was observed, albeit less frequently, which used F-actin comet tails nucleated from the granular membrane. Thus, upon cell stimulation F-actin structures use diverse mechanisms to transport organelles to and from the membrane during the exo-endocytotic cycle taking place in specific areas of cell periphery. | es_ES |
dc.description.sponsorship | This study was supported by grants from the Spanish Ministerio de Economía y Competitividad (BFU2015-63684-P, MINECO, FEDER, UE) to LG. | es_ES |
dc.format | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Frontiers Media | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO//BFU2015-63684-P/ES/BASES MOLECULARES DE LA CITOARQUITECTURA DE LA EXOCITOSIS EN UN MODELO NEUROENDOCRINO/ | es_ES |
dc.relation.ispartof | Frontiers in Cellular Neuroscience | es_ES |
dc.relation.isversionof | Publisher's version | es_ES |
dc.rights | openAccess | es_ES |
dc.title | Multiple mechanisms driving F-actin-dependent transport of organelles to and from secretory sites in bovine chromaffin cells | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.3389/fncel.2018.00344 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.3389/fncel.2018.00344 | es_ES |
dc.identifier.e-issn | 1662-5102 | - |
dc.rights.license | http://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.pmid | 30356839 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
Aparece en las colecciones: | (IN) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
multipcell.pdf | 6,73 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
1
checked on 10-may-2024
SCOPUSTM
Citations
4
checked on 14-may-2024
WEB OF SCIENCETM
Citations
3
checked on 24-feb-2024
Page view(s)
22
checked on 21-may-2024
Download(s)
7
checked on 21-may-2024