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Título: | Early neocortical regionalization in the absence of thalamic innervation |
Autor: | Miyashita-Lin, Emily M.; Hevner, R.; Wassarman, Karen M.; Martínez, Salvador CSIC ORCID; Rubenstein, J. L. R. | Fecha de publicación: | 1999 | Editor: | American Association for the Advancement of Science | Citación: | Science 285(5429): 906-909 (1999) | Resumen: | There is a long-standing controversy regarding the mechanisms that generate the functional subdivisions of the cerebral neocortex. One model proposes that thalamic axonal input specifies these subdivisions; the competing model postulates that patterning mechanisms intrinsic to the dorsal telencephalon generate neocortical regions. Gbx-2mutant mice, whose thalamic differentiation is disrupted, were investigated. Despite the lack of cortical innervation by thalamic axons, neocortical region–specific gene expression (Cadherin-6, EphA-7, Id-2, andRZR-beta) developed normally. This provides evidence that patterning mechanisms intrinsic to the neocortex specify the basic organization of its functional subdivisions. | Versión del editor: | https://doi.org/10.1126/science.285.5429.906 | URI: | http://hdl.handle.net/10261/307550 | DOI: | 10.1126/science.285.5429.906 | ISSN: | 0036-8075 |
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