Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/297192
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Alonso, Ana | es_ES |
dc.contributor.author | Larraga, Jaime | es_ES |
dc.contributor.author | Loayza, Francisco | es_ES |
dc.contributor.author | Martínez, Enrique | es_ES |
dc.contributor.author | Valladares, Basilio | es_ES |
dc.contributor.author | Larraga, Vicente | es_ES |
dc.contributor.author | Alcolea, Pedro J. | es_ES |
dc.date.accessioned | 2023-03-10T10:57:18Z | - |
dc.date.available | 2023-03-10T10:57:18Z | - |
dc.date.issued | 2022-07-04 | - |
dc.identifier.citation | Pathogens 11 (7) 761 (2022) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10261/297192 | - |
dc.description | 15 p.-4 fig.-1 tab. | es_ES |
dc.description.abstract | The compartmentalization of untranslated mRNA molecules in granules occurring in many eukaryotic organisms including trypanosomatids involves the formation of complexes between mRNA molecules and RNA-binding proteins (RBPs). The putative ATP-dependent DEAD/H RNA helicase (DEVH1) from Leishmania infantum (Kinetoplastida: Trypanosomatidae) is one such proteins. The objective of this research is finding differentially expressed genes in a stable episomal transfectant L. infantum promastigote line over-expressing DEVH1 in the stationary phase of growth in axenic culture to get insight into the biological roles of this RNA helicase in the parasite. Interestingly, genes related to parasite survival and virulence factors, such as the hydrophilic surface protein/small hydrophilic endoplasmic reticulum protein (HASP/SHERP) gene cluster, an amastin, and genes related to reactive oxygen species detoxification are down-regulated in DEVH1 transfectant promastigotes. | es_ES |
dc.description.sponsorship | The RICET (RETICS) network funded this research, grant from 2008 to 2020. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Multidisciplinary Digital Publishing Institute | es_ES |
dc.relation.isversionof | Publisher's version | es_ES |
dc.rights | openAccess | es_ES |
dc.subject | DEAD/H RNA helicase | es_ES |
dc.subject | Stable episomal transfection | es_ES |
dc.subject | Induced over-expression | es_ES |
dc.subject | Leishmania infantum | es_ES |
dc.subject | Transcriptom | es_ES |
dc.title | Stable episomal transfectant Leishmania infantum promastigotes over-expressing the DEVH1 RNA helicase gene down-regulate parasite survival genes | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.3390/pathogens11070761 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.3390/pathogens11070761 | es_ES |
dc.identifier.e-issn | 2076-0817 | - |
dc.rights.license | https://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.contributor.orcid | Alonso, Ana [0000-0002-1228-7331] | es_ES |
dc.contributor.orcid | Larraga, Jaime [0000-0001-7293-7239] | es_ES |
dc.contributor.orcid | Valladares, Basilio [0000-0001-6251-2325] | es_ES |
dc.contributor.orcid | Larraga, Vicente [0000-0003-1260-7400] | es_ES |
dc.contributor.orcid | Alcolea, Pedro J. [0000-0002-0729-8941] | es_ES |
dc.subject.uri | http://metadata.un.org/sdg/5 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
dc.subject.sdg | Achieve gender equality and empower all women and girls | es_ES |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.openairetype | artículo | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
Aparece en las colecciones: | (CIB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
pathogens_alonso_2022.pdf | Artículo principal | 1,66 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
1
checked on 20-abr-2024
WEB OF SCIENCETM
Citations
1
checked on 26-feb-2024
Page view(s)
30
checked on 03-may-2024
Download(s)
35
checked on 03-may-2024
Google ScholarTM
Check
Altmetric
Altmetric
Este item está licenciado bajo una Licencia Creative Commons