Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/294744
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Villaverde, A. | es_ES |
dc.contributor.author | Martínez, Miguel Ángel | es_ES |
dc.contributor.author | Sobrino Castelló, Francisco | es_ES |
dc.contributor.author | Dopazo, J. | es_ES |
dc.contributor.author | Moya, A. | es_ES |
dc.contributor.author | Domingo, Esteban | es_ES |
dc.date.accessioned | 2023-02-20T10:41:40Z | - |
dc.date.available | 2023-02-20T10:41:40Z | - |
dc.date.issued | 1991 | - |
dc.identifier.citation | Gene 103(2): 147-153 (1991) | es_ES |
dc.identifier.issn | 0378-1119 | - |
dc.identifier.uri | http://hdl.handle.net/10261/294744 | - |
dc.description.abstract | The number of nucleotide (nt) substitutions found in the VP1 gene (encoding viral capsid protein) between any two of 16 closely related isolates of foot-and-mouth disease virus (FMDV) has been quantified as a function of the time interval between isolations [Villaverde et al.,J. Mol. Biol. 204(1988)771-776]. One of them (isolate C-S12) includes some replacements found in isolates that preceded it and other replacements found in later isolates. The study has revealed alternating periods of rapid evolution and of relative genetic stability of VP1. During a defined period of acute disease, the rate of fixation of replacements at the VP1 coding segment was 6 × 10-3 substitutions per nt per year. Only small differences in the rate of evolution were observed between subsegments within the VP1 gene. The observation of a relatively constant rate of evolution during a disease episode was unexpected. We propose that such constancy may be a consequence of random sampling of mutants from the FMDV quasispecies, followed by their amplification in susceptible hosts (to generate a new quasispecies). Successive sampling and amplification events may result in a steady accumulation of mutations. © 1991. | es |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation.ispartof | Centro de Investigación en Sanidad Animal (CISA) | es_ES |
dc.rights | closedAccess | es_ES |
dc.title | Fixation of mutations at the VP1 gene of foot-and-mouth disease virus. Can quasispecies define a transient molecular clock? | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1016/0378-1119(91)90267-F | - |
dc.relation.csic | Sí | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
dc.issue.number | 2 | es |
dc.journal.title | Gene | es |
dc.page.initial | 147 | es |
dc.page.final | 153 | es |
dc.volume.number | 103 | es |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.openairetype | artículo | - |
Aparece en las colecciones: | (INIA) Artículos |
CORE Recommender
SCOPUSTM
Citations
36
checked on 11-may-2024
WEB OF SCIENCETM
Citations
35
checked on 21-feb-2024
Page view(s)
28
checked on 16-may-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.