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Título: | Single- and joint-population analyses of two experimental pig crosses to confirm quantitative trait loci on Sus scrofa chromosome 6 and leptin receptor effects on fatness and growth traits |
Autor: | Muñoz, G.; Óvilo Martín, Cristina; Silió, Luis; Tomàs, Anna; Noguera, José L.; Rodríguez, M. Carmen | Palabras clave: | Backfat thickness Body weight Joint analysis Leptin receptor Pig Polymorphism |
Fecha de publicación: | 2009 | Editor: | Oxford University Press | Citación: | Journal of Animal Science 87(2): 459-468 (2009) | Resumen: | The primary goal of this study was to detect and confirm QTL on SSC6 for growth and fatness traits in 2 experimental F2 intercrosses Iberian x Landrace (IB x LR) and Iberian x Meishan (IB x MS), which were used in this study for the first time in a QTL analysis related to productive traits. For this purpose, single- and joint-population analyses with single and bivariate trait models of both populations were performed. The presence of the SSC6 QTL for backfat thickness previously identified in the IB x LR cross was detected in this population with additional molecular information, but also was confirmed in the IB x MS cross. In addition, a QTL affecting BW was detected in both crosses in a similar position to the QTL detected for backfat thickness. This is the first study in which a QTL affecting BW is detected on SSC6 in the IB x LR cross, as well as in the IB x MS resource population. Furthermore, we analyzed a previously described nonsynonymous lept in receptor (LEPR) SNP located in exon 14 (c.2002C > T) for causality with respect to this QTL within both F 2 populations. Our results supported the previously reported association between LEPR alleles and backfat thickness in the IB x LR cross, and this association was also confirmed within the IB x MS cross. An association not reported before between LEPR alleles and BW was identified in both populations. © 2009 American Society of Animal Science. All rights reserved. | URI: | http://hdl.handle.net/10261/294085 | DOI: | 10.2527/jas.2008-1127 | ISSN: | 0021-8812 | E-ISSN: | 1525-3163 |
Aparece en las colecciones: | (INIA) Artículos |
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