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http://hdl.handle.net/10261/293777
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Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Martínez, Miguel Ángel | es_ES |
dc.contributor.author | Carrillo García, Mª Cristina | es_ES |
dc.contributor.author | González-Candelas, Fernando | es_ES |
dc.contributor.author | Moya, A. | es_ES |
dc.contributor.author | Domingo, Esteban | es_ES |
dc.contributor.author | Sobrino Castelló, Francisco | es_ES |
dc.date.accessioned | 2023-02-20T10:31:58Z | - |
dc.date.available | 2023-02-20T10:31:58Z | - |
dc.date.issued | 1991 | - |
dc.identifier.citation | Journal of Virology 65(7): 3954-3957 (1991) | es_ES |
dc.identifier.issn | 0022-538X | - |
dc.identifier.uri | http://hdl.handle.net/10261/293777 | - |
dc.description.abstract | We document the rapid alteration of fitness of two foot-and-mouth disease virus (FMDV) mutants resistant to a neutralizing monoclonal antibody. Both mutants showed a selective disadvantage in BHK-21 cells when passaged in competition with their parental FMDV. Upon repeated replication of the mutants alone, they acquired a selective advantage over the parental FMDV and fixed additional genomic substitutions without reversion of the monoclonal antibody-resistant phenotype. Thus, variants that were previously kept at low frequency in the mutant spectrum of a viral quasispecies rapidly became the master sequence of a new genomic distribution and dominated the viral population. | es |
dc.language.iso | eng | es_ES |
dc.publisher | American Society for Microbiology | es_ES |
dc.relation.ispartof | Centro de Investigación en Sanidad Animal (CISA) | es_ES |
dc.rights | closedAccess | es_ES |
dc.title | Fitness alteration of foot-and-mouth disease virus mutants Measurement of adaptability of viral quasispecies | es_ES |
dc.type | artículo | es_ES |
dc.identifier.e-issn | 1098-5514 | - |
dc.relation.csic | Sí | es_ES |
dc.contributor.orcid | González-Candelas, Fernando [0000-0002-0879-5798] | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
dc.issue.number | 7 | es |
dc.journal.title | Journal of Virology | es |
dc.page.initial | 3954 | es |
dc.page.final | 3957 | es |
dc.volume.number | 65 | es |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
Aparece en las colecciones: | (INIA) Artículos |
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