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Título: | Expression of the FUS domain restores liposarcoma development in CHOP transgenic mice |
Autor: | Pérez-Mancera, P. A. CSIC; Pérez-Losada, J. CSIC ORCID ; Sánchez-Martín, M.; Rodríguez-García, M. A.; Flores, Teresa; Battaner, E.; Gutiérrez-Adán, Alfonso CSIC ORCID ; Pintado, B.; Sánchez-García, Isidro | Palabras clave: | Chromosomal abnormality Malignant solid tumors Adipose tissue Cancer development |
Fecha de publicación: | 2002 | Editor: | Springer Nature | Citación: | Oncogene 21: 1679-1684 (2002) | Resumen: | Fusion proteins created by chromosomal abnormalities are key components of mesenchymal cancer development. The most common chromosomal translocation in liposarcomas, t(12;16)(q13;p11), creates the FUS-CHOP fusion gene. In the past, we generated FUS-CHOP and CHOP transgenic mice and have shown that while FUS-CHOP transgenic develop liposarcomas, mice expressing CHOP, which lacks the FUS domain, display essentially normal white adipose tissue (WAT) development, suggesting that the FUS domain of FUS-CHOP plays a specific and critical role in the pathogenesis of liposarcoma. To test the significance of FUS and CHOP domain interactions within a living mouse, we generated mice expressing the FUS domain and crossed them with CHOP-transgenic mice to generate double-transgenic FUSxCHOP animals. Here we report that expression of the FUS domain restores liposarcoma development in CHOP-transgenic mice. Our results provide genetic evidence that FUS and CHOP domains function in trans for the mutual restoration of liposarcoma. These results identify a new mechanism of tumor-associated fusion genes and might have impact beyond myxoid liposarcoma. | URI: | http://hdl.handle.net/10261/291058 | DOI: | 10.1038/sj/onc/1205220 | ISSN: | 0950-9232 | E-ISSN: | 1476-5594 |
Aparece en las colecciones: | (INIA) Artículos |
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