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| Título: | Acetylcholinesterase activity and molecular isoform distribution are altered after focal cerebral ischemia |
Autor: | Sáez-Valero, Javier CSIC ORCID; González-García, Carmen; Ceña, Valentín CSIC ORCID | Fecha de publicación: | 2003 | Editor: | Elsevier | Citación: | Molecular Brain Research 117(2): 240-244 (2003) | Resumen: | Biochemical changes in rat brain acetylcholinesterase (AChE) activity and molecular isoform distribution were studied using the middle cerebral artery occlusion model. After 24 h of permanent focal ischemia, AChE specific activity from infarcted cortex was found to decrease compared with contralateral cortex. Also a decrease in the minor monomeric (G1) form of AChE is response to ischemia was observed. Ischemia-induced AChE decrease was partially diminished by pre-treatment with dizocilpine (MK-801), a neuroprotective NMDA receptor blocker. | Versión del editor: | https://doi.org/10.1016/S0169-328X(03)00324-3 | URI: | http://hdl.handle.net/10261/288365 | DOI: | 10.1016/S0169-328X(03)00324-3 | ISSN: | 0169-328X |
| Aparece en las colecciones: | (IN) Artículos |
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