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Título: | Adaptive Response of Saccharomyces Hosts to Totiviridae L-A dsRNA Viruses Is Achieved through Intrinsically Balanced Action of Targeted Transcription Factors |
Autor: | Ravoitytė, Bazilė; Lukša, Juliana; Wellinger, Ralf Erik CSIC ORCID ; Serva, Saulius; Servienė, Elena | Palabras clave: | Totiviridae dsRNA Transcription Yeast Saccharomyces cerevisiae Saccharomyces paradoxus |
Fecha de publicación: | 9-abr-2022 | Editor: | Molecular Diversity Preservation International | Citación: | Journal of Fungi 8(4): 381 (2022) | Resumen: | Totiviridae L-A virus is a widespread yeast dsRNA virus. The persistence of the L-A virus alone appears to be symptomless, but the concomitant presence of a satellite M virus provides a killer trait for the host cell. The presence of L-A dsRNA is common in laboratory, industrial, and wild yeasts, but little is known about the impact of the L-A virus on the host’s gene expression. In this work, based on high-throughput RNA sequencing data analysis, the impact of the L-A virus on whole-genome expression in three different Saccharomyces paradoxus and S. cerevisiae host strains was analyzed. In the presence of the L-A virus, moderate alterations in gene expression were detected, with the least impact on respiration-deficient cells. Remarkably, the transcriptional adaptation of essential genes was limited to genes involved in ribosome biogenesis. Transcriptional responses to L-A maintenance were, nevertheless, similar to those induced upon stress or nutrient availability. Based on these data, we further dissected yeast transcriptional regulators that, in turn, modulate the cellular L-A dsRNA levels. Our findings point to totivirus-driven fine-tuning of the transcriptional landscape in yeasts and uncover signaling pathways employed by dsRNA viruses to establish the stable, yet allegedly profitless, viral infection of fungi. | Versión del editor: | http://dx.doi.org/10.3390/jof8040381 | URI: | http://hdl.handle.net/10261/280375 | DOI: | 10.3390/jof8040381 | Identificadores: | doi: 10.3390/jof8040381 e-issn: 2309-608X |
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