Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/279353
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Alignment between glioblastoma internal clock and environmental cues ameliorates survival in Drosophila |
Autor: | Jarabo, Patricia CSIC; Barredo, C.G.; de Pablo, C.; Casas-Tinto, Sergio CSIC ORCID; Martín, Francisco A. CSIC ORCID | Fecha de publicación: | 2022 | Editor: | Nature Publishing Group | Citación: | Communications Biology 5 (2022) | Resumen: | Virtually every single living organism on Earth shows a circadian (i.e. “approximately a day”) internal rhythm that is coordinated with planet rotation (i.e. 24 hours). External cues synchronize the central clock of the organism. Consequences of biological rhythm disruptions have been extensively studied on cancer. Still, mechanisms underlying these alterations, and how they favor tumor development remain largely unknown. Here, we show that glioblastoma-induced neurodegeneration also causes circadian alterations in Drosophila. Preventing neurodegeneration in all neurons by genetic means reestablishes normal biological rhythms. Interestingly, in early stages of tumor development, the central pacemaker lengthens its period, whereas in later stages this is severely disrupted. The re-adjustment of the external light:dark period to longer glioblastoma-induced internal rhythms delays glioblastoma progression and ameliorates associated deleterious effects, even after the tumor onset. | Versión del editor: | http://dx.doi.org/10.1038/s42003-022-03600-9 | URI: | http://hdl.handle.net/10261/279353 | DOI: | 10.1038/s42003-022-03600-9 | Identificadores: | doi: 10.1038/s42003-022-03600-9 issn: 2399-3642 |
Aparece en las colecciones: | (IC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
s42003.pdf | 2,74 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
5
checked on 23-abr-2024
WEB OF SCIENCETM
Citations
4
checked on 23-feb-2024
Page view(s)
25
checked on 01-may-2024
Download(s)
31
checked on 01-may-2024
Google ScholarTM
Check
Altmetric
Altmetric
Este item está licenciado bajo una Licencia Creative Commons