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Título: | The regulatory hierarchy following signal integration by the CbrAB two-component cystem: diversity of responses and functions |
Autor: | Monteagudo-Cascales, Elizabet CSIC ORCID; Santero, Eduardo CSIC ORCID; Canosa, Inés CSIC ORCID | Palabras clave: | CbrA–CbrB Signal transduction Carbon metabolism Two-component systems Pseudomonas Azotobacter Carbon catabolite repression |
Fecha de publicación: | 2022 | Editor: | Multidisciplinary Digital Publishing Institute | Citación: | GENES 13(2): 375 (2022) | Resumen: | CbrAB is a two-component system, unique to bacteria of the family Pseudomonaceae, capable of integrating signals and involved in a multitude of physiological processes that allow bacterial adaptation to a wide variety of varying environmental conditions. This regulatory system provides a great metabolic versatility that results in excellent adaptability and metabolic optimization. The two-component system (TCS) CbrA–CbrB is on top of a hierarchical regulatory cascade and interacts with other regulatory systems at different levels, resulting in a robust output. Among the regulatory systems found at the same or lower levels of CbrAB are the NtrBC nitrogen availability adaptation system, the Crc/Hfq carbon catabolite repression cascade in Pseudomonas, or interactions with the GacSA TCS or alternative sigma ECF factor, such as SigX. The interplay between regulatory mechanisms controls a number of physiological processes that intervene in important aspects of bacterial adaptation and survival. These include the hierarchy in the use of carbon sources, virulence or resistance to antibiotics, stress response or definition of the bacterial lifestyle. The multiple actions of the CbrAB TCS result in an important competitive advantage. | Versión del editor: | http://dx.doi.org/10.3390/genes13020375 | URI: | http://hdl.handle.net/10261/274535 | DOI: | 10.3390/genes13020375 | Identificadores: | doi: 10.3390/genes13020375 issn: 2073-4425 |
Aparece en las colecciones: | (EEZ) Artículos (CABD) Artículos |
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2022_Monteagudo_G_OA.pdf | 2,32 MB | Adobe PDF | Visualizar/Abrir |
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