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Título: | Structural MRI of the basal forebrain as predictor of cognitive response to galantamine in healthy older adults—A randomized controlled double-blinded crossover study |
Autor: | Müller, Patrick; Vellage, Anne-Katrin; Schmicker, Marlen; Menze, Inga; Grothe, Michel J. CSIC ORCID; Teipel, Stefan J.; Müller, Notger G. | Palabras clave: | Alzheimer’s disease Basal forebrain Galantamine Magnetic resonance imaging Personalized medicine |
Fecha de publicación: | 5-abr-2021 | Editor: | John Wiley & Sons | Citación: | Alzheimer's and Dementia: Translational Research and Clinical Interventions 7(1): e12153 (2021) | Resumen: | [Introduction] Cholinesterase inhibitors can enhance cognitive functions in healthy elderly and delay cognitive decline in patients with Alzheimer`s disease (AD). However, not everyone benefits from this treatment (non-responders). Current studies show clinical meaningful improvements only in one third of AD patients treated with cholinesterase inhibitors. [Methods] Here we investigate structural magnetic resonance imaging of the basal forebrain cholinergic system volume (BFvol) as a potential predictor of cognitive response to a single dose of galantamine in healthy adults (n = 18; 59 to 75 years). [Results] We observed that the cognitive response to galantamine, more specifically the attention-dependent filtering performance in a delayed match-to-sample working memory task, correlated with BFvol: Only participants with high BFvol showed a significant positive effect of galantamine on the ability to filter out distracting information during the working memory encoding process. [Discussion] Future studies need to assess whether BFvol may serve as a predictor of the galantamine response in AD patients, too. |
Versión del editor: | http://dx.doi.org/10.1002/trc2.12153 | URI: | http://hdl.handle.net/10261/269793 | DOI: | 10.1002/trc2.12153 | Identificadores: | doi: 10.1002/trc2.12153 e-issn: 2352-8737 |
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