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Título: | Application of a low transition temperature mixture for the dispersive liquid–liquid microextraction of illicit drugs from urine samples |
Autor: | Gallo, Valeria; Tomai, Pierpaolo; Lisio, Valerio Di; Bosco, Chiara Dal; D’Angelo, Paola; Fanali, Chiara; D’Orazio, Giovanni; Silvestro, Ilaria; Picó, Yolanda CSIC ORCID; Gentili, Alessandra | Palabras clave: | Low transition temperature mixtures Deep eutectic solvents Dispersive liquid–liquid microextraction Drugs High performance liquid chromatography Illicit drugs Urine Biological samples |
Fecha de publicación: | 2021 | Editor: | Multidisciplinary Digital Publishing Institute | Citación: | Molecules 26(17): 5222 (2021) | Resumen: | The use of psychoactive substances is a serious problem in today’s society and reliable methods of analysis are necessary to confirm their occurrence in biological matrices. In this work, a green sample preparation technique prior to HPLC-MS analysis was successfully applied to the extraction of 14 illicit drugs from urine samples. The isolation procedure was a dispersive liquid–liquid microextraction based on the use of a low transition temperature mixture (LTTM), composed of choline chloride and sesamol in a molar ratio 1:3 as the extracting solvent. This mixture was classified as LTTM after a thorough investigation carried out by FTIR and DSC, which recorded a glass transition temperature at −71 °C. The extraction procedure was optimized and validated according to the main Food and Drug Administration (FDA) guidelines for bioanalytical methods, obtaining good figures of merit for all parameters: the estimated lower limit of quantitation (LLOQ) values were between 0.01 µg L−1 (bk-MMBDB) and 0.37 µg L−1 (PMA); recoveries, evaluated at very low spike levels (in the ng-µg L−1 range), spanned from 55% (MBDB) to 100% (bk-MMBDB and MDPV); finally, both within-run and between-run precisions were lower than 20% (LLOQ) and 15% (10xLLOQ). | Descripción: | © 2021 by the authors. | Versión del editor: | http://dx.doi.org/10.3390/molecules26175222 | URI: | http://hdl.handle.net/10261/266200 | DOI: | 10.3390/molecules26175222 | E-ISSN: | 1420-3049 |
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Application_of_a_Low_Transition_Gallo_PV_Art2021.pdf | 1,8 MB | Adobe PDF | Visualizar/Abrir |
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