Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/263926
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Coordination between cell proliferation and apoptosis after DNA damage in Drosophila |
Autor: | Ruiz-Losada, Mireya; González, Raúl; Peropadre, Ana; Gil-Gálvez, Alejandro CSIC ORCID; Tena, Juan J. CSIC ORCID; Baonza, Antonio; Estella, Carlos | Fecha de publicación: | 25-nov-2021 | Citación: | Cell Death and Differentiation (2021) | Resumen: | Exposure to genotoxic stress promotes cell cycle arrest and DNA repair or apoptosis. These ¿life¿ or ¿death¿ cell fate decisions often rely on the activity of the tumor suppressor gene p53. Therefore, the precise regulation of p53 is essential to maintain tissue homeostasis and to prevent cancer development. However, how cell cycle progression has an impact on p53 cell fate decision-making is mostly unknown. In this work, we demonstrate that Drosophila p53 proapoptotic activity can be impacted by the G2/M kinase Cdk1. We find that cell cycle arrested or endocycle-induced cells are refractory to ionizing radiation-induced apoptosis. We show that p53 binding to the regulatory elements of the proapoptotic genes and its ability to activate their expression is compromised in experimentally arrested cells. Our results indicate that p53 genetically and physically interacts with Cdk1 and that p53 proapoptotic role is regulated by the cell cycle status of the cell. We propose a model in which cell cycle progression and p53 proapoptotic activity are molecularly connected to coordinate the appropriate response after DNA damage. | Versión del editor: | http://dx.doi.org/10.1038/s41418-021-00898-6 | URI: | http://hdl.handle.net/10261/263926 | DOI: | 10.1038/s41418-021-00898-6 | Identificadores: | doi: 10.1038/s41418-021-00898-6 issn: 1476-5403 |
Aparece en las colecciones: | (CBM) Artículos (CABD) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
EstellaC._CoordinationBetweenCell.pdf | 8,25 MB | Unknown | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
15
checked on 15-may-2024
WEB OF SCIENCETM
Citations
13
checked on 29-feb-2024
Page view(s)
78
checked on 21-may-2024
Download(s)
81
checked on 21-may-2024
Google ScholarTM
Check
Altmetric
Altmetric
Este item está licenciado bajo una Licencia Creative Commons