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Título: | Infectious triggers and novel therapeutic opportunities in childhood B cell leukaemia |
Autor: | Cobaleda, César CSIC ORCID; Vicente-Dueñas, Carolina CSIC ORCID; Sánchez García, Isidro CSIC ORCID | Palabras clave: | B cells Tumour immunology |
Fecha de publicación: | sep-2021 | Editor: | Springer Nature | Citación: | Nature Reviews Immunology 21: 570-581 (2021) | Resumen: | B cell acute lymphoblastic leukaemia (B-ALL) is the most common form of childhood cancer. Although treatment has advanced remarkably in the past 50 years, it still fails in ~20% of patients. Recent studies revealed that more than 5% of healthy newborns carry preleukaemic clones that originate in utero, but only a small percentage of these carriers will progress to overt B-ALL. The drivers of progression are unclear, but B-ALL incidence seems to be increasing in parallel with the adoption of modern lifestyles. Emerging evidence shows that a major driver for the conversion from the preleukaemic state to the B-ALL state is exposure to immune stressors, such as infection. Here, we discuss our current understanding of the environmental triggers and genetic predispositions that may lead to B-ALL, highlighting lessons from epidemiology, the clinic and animal models, and identifying priority areas for future research. | Versión del editor: | http://dx.doi.org/10.1038/s41577-021-00505-2 | URI: | http://hdl.handle.net/10261/261600 | DOI: | 10.1038/s41577-021-00505-2 | ISSN: | 1474-1733 | E-ISSN: | 1474-1741 |
Aparece en las colecciones: | (IBMCC) Artículos (CBM) Artículos |
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Cobaleda_NatureRevImm_2021.pdf | 622,24 kB | Adobe PDF | Visualizar/Abrir |
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