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http://hdl.handle.net/10261/261302
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Blanco González, Guillermo | es_ES |
dc.contributor.author | Sánchez García, Borja | es_ES |
dc.contributor.author | Ruíz García, Lorena | es_ES |
dc.contributor.author | Fdez-Riverola, Florentino | es_ES |
dc.contributor.author | Margolles Barros, Abelardo | es_ES |
dc.contributor.author | Lourenço, Anália | es_ES |
dc.date.accessioned | 2022-02-18T13:20:11Z | - |
dc.date.available | 2022-02-18T13:20:11Z | - |
dc.date.issued | 2021 | - |
dc.identifier | doi: 10.1109/TCBB.2020.2978461 | - |
dc.identifier | e-issn: 1557-9964 | - |
dc.identifier | issn: 1545-5963 | - |
dc.identifier.citation | IEEE/ACM Transactions on Computational Biology and Bioinformatics 18(6): 2302-2313 (2021) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10261/261302 | - |
dc.description.abstract | Glycoside hydrolases are responsible for the enzymatic deconstruction of complex carbohydrates. Most of the families are known to conserve the catalytic machinery and molecular mechanisms. This work introduces a new method to predict glycolytic abilities in sequenced genomes and thus, gain a better understanding of how to target specific carbohydrates and identify potentially interesting sources of specialised enzymes. Genome sequences are aligned to those of organisms with expertly curated glycolytic abilities. Clustering of homology scores helps identify organisms that share common abilities and the most promising organisms regarding specific glycolytic abilities. The method has been applied to members of the bacterial families Ruminococcaceae (39 genera), Eubacteriaceae (11 genera) and Lachnospiraceae (59 genera), which hold major representatives of the human gut microbiota. The method predicted the potential presence of glycoside hydrolases in 1701 species of these genera. Here, the validity and practical usefulness of the method is discussed based on the predictions obtained for members of the genus Ruminococcus. Results were consistent with existing literature and offer useful, complementary insights to comparative genomics and physiological testing. The implementation of the Gleukos web portal (http://sing-group.org/gleukos) offers a public service to those interested in targeting microbial carbohydrate metabolism for biotechnological and health applications. | - |
dc.description.sponsorship | This work was funded by the Spanish “Ministerio de Economía y Competitividad – Agencia Estatal de Investigación” (grant AGL2016-78311-R; AEI/FEDER, UE) and by the grant DI/2018/000236 from the Government of the Principality of Asturias. This study was also supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2019 unit and the Consellería de Educación, Universidades e Formación Profesional (Xunta de Galicia) under the scope of the strategic funding of ED431C2018/55-GRC Competitive Reference Group | - |
dc.language | eng | - |
dc.publisher | Institute of Electrical and Electronics Engineers | es_ES |
dc.relation | nfo:eu-repo/grantAgreement/MINECO/AGL2016-78311-R | - |
dc.rights | closedAccess | - |
dc.subject | Carbohydrates | - |
dc.subject | Glycoside hydrolases | - |
dc.subject | Computational screening | - |
dc.subject | Homology clustering. | - |
dc.title | Computational Approach to the Systematic Prediction of Glycolytic Abilities: Looking Into Human Microbiota | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1109/TCBB.2020.2978461 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1109/TCBB.2020.2978461 | - |
dc.date.updated | 2022-02-18T13:20:11Z | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Agencia Estatal de Investigación (España) | - |
dc.contributor.funder | Principado de Asturias | - |
dc.contributor.funder | Fundação para a Ciência e a Tecnologia (Portugal) | - |
dc.contributor.funder | Xunta de Galicia | - |
dc.relation.csic | Sí | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011033 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100001871 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100011941 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100010801 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.openairetype | artículo | - |
item.fulltext | No Fulltext | - |
Aparece en las colecciones: | (IBFG) Artículos (IPLA) Artículos (MNCN) Artículos |
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