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Título: | An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants |
Autor: | Du, Wenjuan; Hurdiss, Daniel L.; Drabek, Dubravka; Mykytyn, Anna Z.; Kaiser, Franziska K.; González-Hernandez, Mariana; Muñoz-Santos, Diego; Lamers, Mart M.; Haperen, Rien van; Li, Wentao; Drulyte, Ieva; Wang, Chunyan; Solá Gurpegui, Isabel CSIC ORCID ; Armando, Federico; Beythien, Georg; Ciurkiewicz, Malgorzata; Baumgärtner, Wolfgang; Guilfoyle, Kate; Smits, Tony; Lee, Joline van der; Kuppeveld, Frank J. M. van; Amerongen, Geert van; Haagmans, Bart L.; Enjuanes Sánchez, Luis CSIC ORCID ; Osterhaus, Albert D. M. E.; Grosveld, Frank; Bosch, Berend Jan | Fecha de publicación: | 17-feb-2022 | Editor: | BioRxiv | Citación: | BioRxiv: 10.1101/2022.02.17.480751 (2022) | Resumen: | The ongoing evolution of SARS-CoV-2 has resulted in the emergence of Omicron, which displays striking immune escape potential. Many of its mutations localize to the spike protein ACE2 receptor-binding domain, annulling the neutralizing activity of most therapeutic monoclonal antibodies. Here we describe a receptor-blocking human monoclonal antibody, 87G7, that retains ultrapotent neutralization against SARS-CoV-2 variants including the Alpha, Beta, Gamma, Delta and Omicron (BA.1/BA.2) Variants-of-Concern (VOCs). Structural analysis reveals that 87G7 targets a patch of hydrophobic residues in the ACE2-binding site that are highly conserved in SARS-CoV-2 variants, explaining its broad neutralization capacity. 87G7 protects mice and/or hamsters against challenge with all current SARS-CoV-2 VOCs. Our findings may aid the development of sustainable antibody-based strategies against COVID-19 that are more resilient to SARS-CoV-2 antigenic diversity. | Versión del editor: | https://doi.org/10.1101/2022.02.17.480751 | URI: | http://hdl.handle.net/10261/261249 | DOI: | 10.1101/2022.02.17.480751 |
Aparece en las colecciones: | (PTI Salud Global) Colección Especial COVID-19 (CNB) Artículos |
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