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Título: | Synthesis of New Statin Derivatives |
Autor: | Chioua, Mourad CSIC ORCID ; Marco-Contelles, José CSIC ORCID | Palabras clave: | Heterocycles Michaelreaction Nitrones Statins Synthetic Methods |
Fecha de publicación: | 2021 | Editor: | ChemPubSoc Europe | Citación: | ChemistrySelect 6: 13633- 13635 (2021) | Resumen: | Herein we report the synthesis of the new statin derivative MC609 in 80 % overall yield by sequential transformation of simvastatin including dehydration, and Michael addition of N-benzyl hydroxylamine followed by cyclization. The preparation of nitronestatins MC649 and MC645 is also described from (2S,4R)-4-((tert-butyldimethylsilyl)oxy)-6-oxotetrahydro-2H-pyran-2-carbaldehyde by reaction with N-benzyl hydroxylamine, and N-hydroxylamine followed by reduction with sodium cyanoborohydride and coupling with commercially available 2-chloro-6-methylquinoline-3-carbaldehyde, in 77 % and 24 % overall yield, respectively. | Versión del editor: | http://dx.doi.org/10.1002/slct.202103544 | URI: | http://hdl.handle.net/10261/260868 | DOI: | 10.1002/slct.202103544 | Identificadores: | doi: 10.1002/slct.202103544 issn: 2365-6549 |
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