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Título: | The oscillatory profile induced by the anxiogenic drug fg-7142 in the amygdala-hippocampal network is reversed by infralimbic deep brain stimulation: Relevance for mood disorders |
Autor: | Vila-Merkle, Hanna; González-Martínez, Alicia; Campos-Jiménez, Rut; Martínez-Ricós, Joana; Teruel-Martí, Vicent; Blasco-Serra, Arantxa; Lloret, Ana; Celada, Pau CSIC ORCID; Cervera-Ferri, Ana | Palabras clave: | Oscillations Anxiety Deep brain stimulation Electrophysiology Prefrontal Hippocampus Amygdala |
Fecha de publicación: | 6-jul-2021 | Editor: | Molecular Diversity Preservation International | Citación: | Biomedicines 9(7): 783 (2021) | Resumen: | Anxiety and depression exhibit high comorbidity and share the alteration of the amygdala-hippocampal-prefrontal network, playing different roles in the ventral and dorsal hippocampi. Deep brain stimulation of the infralimbic cortex in rodents or the human equivalent-the subgenual cingulate cortex-constitutes a fast antidepressant treatment. The aim of this work was: (1) to describe the oscillatory profile in a rodent model of anxiety, and (2) to deepen the therapeutic basis of infralimbic deep brain stimulation in mood disorders. First, the anxiogenic drug FG-7142 was administered to anaesthetized rats to characterize neural oscillations within the amygdala and the dorsoventral axis of the hippocampus. Next, deep brain stimulation was applied. FG-7142 administration drastically reduced the slow waves, increasing delta, low theta, and beta oscillations in the network. Moreover, FG-7142 altered communication in these bands in selective subnetworks. Deep brain stimulation of the infralimbic cortex reversed most of these FG-7142 effects. Cross-frequency coupling was also inversely modified by FG-7142 and by deep brain stimulation. Our study demonstrates that the hyperactivated amygdala-hippocampal network associated with the anxiogenic drug exhibits an oscillatory fingerprint. The study contributes to comprehending the neurobiological basis of anxiety and the effects of infralimbic deep brain stimulation. | Versión del editor: | http://dx.doi.org/10.3390/biomedicines9070783 | URI: | http://hdl.handle.net/10261/260413 | DOI: | 10.3390/biomedicines9070783 | Identificadores: | doi: 10.3390/biomedicines9070783 e-issn: 2227-9059 |
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