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http://hdl.handle.net/10261/255964
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Fusco, Giuliana | es_ES |
dc.contributor.author | Chen, Serene W. | es_ES |
dc.contributor.author | Williamson, Philip T. F. | es_ES |
dc.contributor.author | Cascella, Roberta | es_ES |
dc.contributor.author | Perni, Michele | es_ES |
dc.contributor.author | Jarvis, James A. | es_ES |
dc.contributor.author | Cecchi, Cristina | es_ES |
dc.contributor.author | Vendruscolo, Michele | es_ES |
dc.contributor.author | Chiti, Fabrizio | es_ES |
dc.contributor.author | Cremades, Nunilo | es_ES |
dc.contributor.author | Ying, Liming | es_ES |
dc.contributor.author | Dobson, Christopher M. | es_ES |
dc.contributor.author | De Simone, Alfonso | es_ES |
dc.date.accessioned | 2021-12-14T12:29:41Z | - |
dc.date.available | 2021-12-14T12:29:41Z | - |
dc.date.issued | 2017-12-15 | - |
dc.identifier.citation | Science 358 (6369): 1440- (2017) | es_ES |
dc.identifier.issn | 0036-8075 | - |
dc.identifier.uri | http://hdl.handle.net/10261/255964 | - |
dc.description | 5 pags, 3 figs | es_ES |
dc.description.abstract | Oligomeric species populated during the aggregation process of a-synuclein have been linked to neuronal impairment in Parkinson's disease and related neurodegenerative disorders. By using solution and solid-state nuclear magnetic resonance techniques in conjunction with other structural methods, we identified the fundamental characteristics that enable toxic a-synuclein oligomers to perturb biological membranes and disrupt cellular function; these include a highly lipophilic element that promotes strong membrane interactions and a structured region that inserts into lipid bilayers and disrupts their integrity. In support of these conclusions, mutations that target the region that promotes strong membrane interactions by a-synuclein oligomers suppressed their toxicity in neuroblastoma cells and primary cortical neurons. | es_ES |
dc.description.sponsorship | This research was supported by Parkinson's UK (G-1508 to G.F., M.V., C.M.D., and A.D.); the UK Medical Research Council (MR/N000676/1 to G.F., M.V. C.M.D., and A.D.); the Wellcome Trust (104933/2/14E to kD.): the Leverhulme Trust (RPG-2015-350 to A.D. and RPG-2015-345 to L.Y.); the British Heart Foundation (PG/14/93/31237 to A.D. and PG/11/81/29130 to L.Y.); the UK Biotechnology and Biological Sciences Research Council (BB/M023923/1 to A.D. and BB/G00594X/1 to L.Y.); the Agency of Science, Technology and Research of Singapore (to S.W.C.); the Ministry of Economy, Industry, and Competitiveness of Spain (MINECO RYC-2012-12068 and MINECO/FEDER EU BEU2015-64119-P to N.C.); the Regione Toscana (SUPREMAL to E.C., C.C., and R.C); the University of Florence (Eondi di Ateneo to E.C. and. C.C); and the Centre for Misfolding Diseases of the University of Cambridge. The data supporting the findings of this study are available within the article and supplementary materials. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Association for the Advancement of Science | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/RYC-2012-12068 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BEU2015-64119-P | es_ES |
dc.relation.isversionof | Postprint | es_ES |
dc.rights | openAccess | es_ES |
dc.title | Structural basis of membrane disruption and cellular toxicity by a-synuclein oligomers | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1126/science.aan6160 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.identifier.e-issn | 1095-9203 | - |
dc.contributor.funder | Parkinson's Disease Society (UK) | es_ES |
dc.contributor.funder | Medical Research Council (UK) | es_ES |
dc.contributor.funder | Wellcome Trust | es_ES |
dc.contributor.funder | Leverhulme Trust | es_ES |
dc.contributor.funder | British Heart Foundation | es_ES |
dc.contributor.funder | Biotechnology and Biological Sciences Research Council (UK) | es_ES |
dc.contributor.funder | Agency for Science, Technology and Research A*STAR (Singapore) | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.contributor.funder | Regione Toscana | es_ES |
dc.contributor.funder | Università degli Studi di Firenze | es_ES |
dc.contributor.funder | University of Cambridge | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100001348 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000268 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000274 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000275 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000265 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100009888 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000735 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004434 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100004440 | es_ES |
dc.identifier.pmid | 29242346 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | artículo | - |
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