Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/240902
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Novel Functions of IFI44L as a Feedback Regulator of Host Antiviral Responses |
Autor: | DeDiego, Marta L. CSIC ORCID ; Martínez-Sobrido, Luis; Topham, David J. | Palabras clave: | Innate immunity Antiviral responses Type I and III interferon responses Signaling transduction Interferon-induced protein IFI44L FKBP5 IKKε kinase activity IKKβ kinase activity IRF-3 phosphorylation IκBα phosphorylation IKK kinase activity |
Fecha de publicación: | nov-2019 | Editor: | American Society for Microbiology | Citación: | Journal of Virology 93(21): e01159-19 (2019) | Resumen: | We describe a novel function for the interferon (IFN)-induced protein 44-like (IFI44L) gene in negatively modulating innate immune responses induced after virus infections. Furthermore, we show that decreasing IFI44L expression impairs virus production and that IFI44L expression negatively modulates the antiviral state induced by an analog of double-stranded RNA (dsRNA) or by IFN treatment. The mechanism likely involves the interaction of IFI44L with cellular FK506-binding protein 5 (FKBP5), which in turn interacts with kinases essential for type I and III IFN responses, such as inhibitor of nuclear factor kappa B (IκB) kinase alpha (IKKα), IKKβ, and IKKε. Consequently, binding of IFI44L to FKBP5 decreased interferon regulatory factor 3 (IRF-3)-mediated and nuclear factor kappa-B (NF-κB) inhibitor (IκBα)-mediated phosphorylation by IKKε and IKKβ, respectively. According to these results, IFI44L is a good target for treatment of diseases associated with excessive IFN levels and/or proinflammatory responses and for reduction of viral replication. | Versión del editor: | http://dx.doi.org/10.1128/JVI.01159-19 | URI: | http://hdl.handle.net/10261/240902 | DOI: | 10.1128/JVI.01159-19 | Identificadores: | doi: 10.1128/JVI.01159-19 issn: 1098-5514 |
Aparece en las colecciones: | (CNB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
Page view(s)
83
checked on 20-may-2024
Download(s)
14
checked on 20-may-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.