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Título: | Modulating protein-protein interactions by cyclic and macro-cyclic peptides. Prominent strategies and examples |
Autor: | González-Muñiz, Rosario CSIC ORCID; Bonache de Marcos, María Ángeles CSIC ORCID ; Pérez de Vega, M. Jesús CSIC ORCID | Palabras clave: | Cyclic peptides macrocyclic peptides protein–protein interactions Computational design biochemical methodologies synthetic strategies cell penetrating conjugates peptoids |
Fecha de publicación: | 2021 | Editor: | Molecular Diversity Preservation International | Citación: | Molecules 26: 445-464 (2021) | Resumen: | Cyclic and macrocyclic peptides constitute advanced molecules for modulating protein–protein interactions (PPIs). Although still peptide derivatives, they are metabolically more stable than linear counterparts, and should have a lower degree of flexibility, with more defined secondary structure conformations that can be adapted to imitate protein interfaces. In this review, we analyze recent progress on the main methods to access cyclic/macrocyclic peptide derivatives, with emphasis in a few selected examples designed to interfere within PPIs. These types of peptides can be from natural origin, or prepared by biochemical or synthetic methodologies, and their design could be aided by computational approaches. Some advances to facilitate the permeability of these quite big molecules by conjugation with cell penetrating peptides, and the incorporation of β-amino acid and peptoid structures to improve metabolic stability, are also commented. It is predicted that this field of research could have an important future mission, running in parallel to the discovery of new, relevant PPIs involved in pathological processes | Versión del editor: | http://dx.doi.org/10.3390/molecules26020445 | URI: | http://hdl.handle.net/10261/237622 | DOI: | 10.3390/molecules26020445 | Identificadores: | doi: 10.3390/molecules26020445 issn: 1420-3049 |
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molecules-26-00445-1.pdf | 1,31 MB | Adobe PDF | Visualizar/Abrir |
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