Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/237467
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | The impact of freezing of gait on functional dependency in Parkinson’s disease with regard to motor phenotype |
Autor: | Santos-García, Diego; Deus Fonticoba, T. de; Suárez-Castro. Ester; Aneiros Díaz, A.; Feal Panceiras, M. J.; Paz González, J. M.; García-Sancho, Carlos; Jesús Maestre, Silvia CSIC ORCID; Mir, Pablo CSIC ORCID; Planellas, Lluís; García Caldentey, Juan; Caballol, Nuria; Legarda, Inés; Hernández-Vara, Jorge; González-Aramburu, Isabel; Ávila-Rivera, María A.; Catalán, M. J.; Nogueira, Víctor; Álvarez-Sauco, María; Vela-Desojo, Lydia; Escalante, Sonia; Cubo, Esther; Sánchez Alonso, Pilar; Alonso Losada, María G.; López-Ariztegui, Nuria; Martínez-Martín, Pablo | Palabras clave: | Activities of daily living Freezing Functional dependency Gait Parkinson’s disease |
Fecha de publicación: | oct-2020 | Editor: | Springer Nature | Citación: | Neurological Sciences 41: 2883-2892 (2020) | Resumen: | Background and objective: Freezing of gait (FOG) is a disabling symptom more frequent in Parkinson’s disease (PD) patients with postural instability gait difficulty (PIGD) phenotype. The aim of this study was to determine the prevalence of self-reported FOG in a large group of PD patients as well as assess its relationship with functional dependency with regard to motor phenotype. Methods: The data correspond to the baseline evaluation of the COPPADIS-2015 study. Patients with FOG were identified as those with a score of 1 or greater on item-3 of the freezing of gait questionnaire (FOG-Q). Functional dependency was defined as a Schwab and England (S&E) ADL scale score less than 80%. PIGD and non-PIGD (tremor dominant + indeterminate) groups were considered regarding to motor phenotype. Results: Among the 689 PD patients (62.6 ± 8.9 years old, 59.8% males), 240 reported FOG (34.8%), whereas 63 presented functional dependency (9.1%). A total of 22.1% of patients with FOG presented functional dependency vs. only 2.2% of those without FOG (p < 0.0001). FOG was related to functional dependency (OR = 3.470; 95%CI 1.411–8.530; p = 0.007) after adjustment to age, gender, disease duration, daily equivalent levodopa dose, comorbidity (number of non-antiparkinsonian drugs/day), motor status (UPDRS-III), PIGD phenotype, motor complications (UPDRS-IV), NMS burden (NMSS total score), cognition (PD-CRS), and mood (BDI-II). However, according to motor phenotype, FOG was related to functional dependency only in PIGD patients (OR = 7.163; 95%CI 1.206–42.564; p = 0.030). Conclusions: Self-reported FOG is associated with functional dependency in PIGD but not in non-PIGD motor phenotype patients. | Versión del editor: | http://dx.doi.org/10.1007/s10072-020-04404-7 | URI: | http://hdl.handle.net/10261/237467 | DOI: | 10.1007/s10072-020-04404-7 | Identificadores: | doi: 10.1007/s10072-020-04404-7 e-issn: 1590-3478 issn: 1590-1874 |
Aparece en las colecciones: | (IBIS) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
12
checked on 18-mar-2024
WEB OF SCIENCETM
Citations
11
checked on 14-feb-2024
Page view(s)
101
checked on 19-mar-2024
Download(s)
19
checked on 19-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.