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Título: | Integrating Comorbidities and Phenotype-Based Medicine in Patient-Centered Medicine in COPD |
Autor: | López-Campos, J. L. CSIC ORCID; Ruiz-Duque, Borja; Carrasco Hernández, Laura CSIC; Caballero-Eraso, Candela CSIC ORCID | Palabras clave: | COPD Clinical phenotypes Comorbidities Personalized medicine |
Fecha de publicación: | 25-ago-2020 | Editor: | Multidisciplinary Digital Publishing Institute | Citación: | Journal of Clinical Medicine 9(9): 2745 (2020) | Resumen: | Despite recent notable innovations in the management of chronic obstructive pulmonary disease (COPD), no major advances in patient-centered medicine have been achieved. Current guidelines base their proposals on the average results from clinical trials, leading to what could be termed ‘means-based’ medical practice. However, the therapeutic response is variable at the patient level. Additionally, the variability of the clinical presentation interacts with comorbidities to form a complex clinical scenario for clinicians to deal with. Consequently, no consensus has been reached over a practical approach for combining comorbidities and disease presentation markers in the therapeutic algorithm. In this context, from the patients’ first visit, the clinician faces four major dilemmas: (1) establishing the correct diagnosis of COPD as opposed to other airway diseases, such as bronchial asthma; (2) deciding on the initial therapeutic approach based on the clinical characteristics of each case; (3) setting up a study strategy for non-responding patients; (4) pursuing a follow-up strategy with two well-defined periods according to whether close or long-term follow-up is required. Here, we will address these major dilemmas in the search for a patient-centered approach to COPD management and suggest how to combine them all in a single easy-to-use strategy. | Descripción: | This article belongs to the Special Issue Current Perspectives in Management of Chronic Obstructive Pulmonary Disease. | Versión del editor: | http://doi.org/10.3390/jcm9092745 | URI: | http://hdl.handle.net/10261/236555 | DOI: | 10.3390/jcm9092745 | Identificadores: | doi: 10.3390/jcm9092745 e-issn: 2077-0383 |
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Phenotype-Based_Medicine.pdf | 1,22 MB | Adobe PDF | Visualizar/Abrir |
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