Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody

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Título:	Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody
Autor:	Macías-León, Javier; Bermejo, I. A.; Asín, A.; García García, Ana Belén CSIC; Compañón, Ismael; Jiménez-Moreno, Ester CSIC ORCID; Coelho, Helena; Mangini, V.; Albuquerque, I.S.; Marcelo, Filipa CSIC ORCID; Asensio, Juan Luis CSIC ORCID; Bernardes, G. J. L.; Joshi, H. J.; Fiammengo, R.; Blixt, O.; Hurtado-Guerrero, Ramón CSIC ORCID; Corzana, Francisco
Fecha de publicación:	2020
Editor:	Royal Society of Chemistry (UK)
Citación:	Chemical Communications 56: 15137-15140 (2020)
Resumen:	The molecular basis of antibody 5E5, which recognizes the entire GalNAc unit as a primary epitope is disclosed. The antibody's contacts with the peptide are mostly limited to two residues, allowing it to show some degree of promiscuity. These findings open the door to the chemical design of peptide-mimetics for developing efficient anti-cancer vaccines and diagnostic tools. This journal is
Versión del editor:	http://dx.doi.org/10.1039/d0cc06349e
URI:	http://hdl.handle.net/10261/231221
DOI:	10.1039/d0cc06349e
Identificadores:	doi: 10.1039/d0cc06349e issn: 1359-7345 e-issn: 1364-548X
Aparece en las colecciones:	(IQOG) Artículos

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