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Título: | The Role of Extracellular Vesicles in Demyelination of the Central Nervous System |
Autor: | López-Guerrero, José Antonio CSIC ORCID; Ripa, Inés CSIC ORCID; Andreu, Sabina; Bello, Raquel CSIC ORCID | Palabras clave: | Extracellular vesicles Demyelination Central nervous system Multiple sclerosis Neuromyelitis optica Progressive multifocal leukoencephalopathy Herpesviruses Herpesviruses |
Fecha de publicación: | 30-nov-2020 | Editor: | Multidisciplinary Digital Publishing Institute | Citación: | International Journal of Molecular Sciences 21(23): 9111 (2020) | Resumen: | It is being increasingly demonstrated that extracellular vesicles (EVs) are deeply involved in the physiology of the central nervous system (CNS). Processes such as synaptic activity, neuron-glia communication, myelination and immune response are modulated by EVs. Likewise, these vesicles may participate in many pathological processes, both as triggers of disease or, on the contrary, as mechanisms of repair. EVs play relevant roles in neurodegenerative disorders such as Alzheimer’s or Parkinson’s diseases, in viral infections of the CNS and in demyelinating pathologies such as multiple sclerosis (MS). This review describes the involvement of these membrane vesicles in major demyelinating diseases, including MS, neuromyelitis optica, progressive multifocal leukoencephalopathy and demyelination associated to herpesviruses. | URI: | http://hdl.handle.net/10261/225667 | DOI: | 10.3390/ijms21239111 | E-ISSN: | 1422-0067 | Identificadores: | doi: 10.3390/ijms21239111 |
Aparece en las colecciones: | (CIB) Artículos |
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ijms-21-09111.pdf | 1,28 MB | Adobe PDF | Visualizar/Abrir |
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